Synthesis of O-(beta-hydroxyethyl) derivatives of diosmetin

被引：0

作者：

Mosquera, R ^{[1
]}

Orjales, A ^{[1
]}

机构：

[1] FAES SA, RES DEPT, E-48080 BILBAO, SPAIN

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1996年 / 35卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five O-(beta-hydroxyethyl) derivatives (3, 4, 5, 6, 7) of diosmetin have been synthesized for the first time. Compounds 3 and 6 have been obtained by hydrolysis of 3'-O-(beta-hydroxyethyl)- and 3',5-di-O-(beta-hydroxyethyl)diosmin, respectively. Compound 4 has been prepared from diosmetin, after protecting the hydroxyls at C-7 and C-3', using ethylene oxide or ethyl chloroacetate and sodium borohydride, followed by removal of the protective groups. Compounds 5 and 7 have been prepared by the reaction of diosmetin (8) and 6 with ethylene chlorohydrin, respectively.

引用

页码：19 / 22

页数：4

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