Oxytocin receptor (OXTR) polymorphisms and attachment in human infants

被引：82

作者：

Chen, Frances S. ^{[1
]}

Barth, Maria E. ^{[2
]}

Johnson, Stephen L. ^{[3
]}

Gotlib, Ian H. ^{[4
]}

Johnson, Susan C. ^{[5
]}

机构：

[1] Univ Freiburg, Dept Psychol, D-79104 Freiburg, Germany

[2] Tufts Univ, Dept Psychol, Boston, MA 02111 USA

[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[4] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA

[5] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA

来源：

FRONTIERS IN PSYCHOLOGY | 2011年 / 2卷

关键词：

attachment; trust; development; oxytocin; polymorphisms; GENE OXTR; STRESS REACTIVITY; SOCIAL COGNITION; ASSOCIATION; SENSITIVITY; INTERACT; DEFICITS; ANXIETY; AUTISM; ALLELE;

D O I：

10.3389/fpsyg.2011.00200

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Ordinary variations in human infants' attachment behaviors their proclivity to seek and accept comfort from caregivers are associated with a wide range of individual differences in psychological functioning in adults The current investigation examined variation in the oxytocin receptor (OXTR) gene as one possible source of these variations in infant attachment. One hundred seventy-six infants (77 Caucasian, 99 non Caucasian) were classified as securely or insecurely attached based on their behavior in the Strange Situation (Ainsworth et al., 1978). The A allele of OXTR rs2254298 was associated with attachment security in the non-Caucasian infants (p < 0.005). These findings underscore the importance of oxytocin in the development of human social behavior and support its role in social stress regulation and the development of trust.

引用

页数：6

共 51 条

[21] HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR, stress, and depression [J].

Gotlib, Ian H. ;

Joormann, Jutta ;

Minor, Kelly L. ;

Hallmayer, Joachim .

BIOLOGICAL PSYCHIATRY, 2008, 63 (09) :847-851

[22]

Greenberg T., 1999, HDB ATTACHMENT, P269

[23] Oxytocin increases gaze to the eye region of human faces [J].

Guastella, Adam J. ;

Mitchell, Philip B. ;

Dadds, Mark R. .

BIOLOGICAL PSYCHIATRY, 2008, 63 (01) :3-5

[24] Oxytocin increases retention of social cognition in autism [J].

Hollander, Eric ;

Bartz, Jennifer ;

Chaplin, William ;

Phillips, Ann ;

Sumner, Jennifer ;

Soorya, Latha ;

Anagnostou, Evdokia ;

Wasserman, Stacey .

BIOLOGICAL PSYCHIATRY, 2007, 61 (04) :498-503

[25] Association Between the Oxytocin Receptor Gene and Amygdalar Volume in Healthy Adults [J].

Inoue, Hideyuki ;

Yamasue, Hidenori ;

Tochigi, Mamoru ;

Abe, Osamu ;

Liu, Xiaoxi ;

Kawamura, Yoshiya ;

Takei, Kunio ;

Suga, Motomu ;

Yamada, Haruyasu ;

Rogers, Mark A. ;

Aoki, Shigeki ;

Sasaki, Tsukasa ;

Kasai, Kiyoto .

BIOLOGICAL PSYCHIATRY, 2010, 68 (11) :1066-1072

[26]

Insel TR, 1997, AM J PSYCHIAT, V154, P726

[27] Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism [J].

Jacob, Suma ;

Brune, Camille W. ;

Carter, C. S. ;

Leventhal, Bennett L. ;

Lord, Catherine ;

Cook, Edwin H., Jr. .

NEUROSCIENCE LETTERS, 2007, 417 (01) :6-9

[28] Evidence for infants' internal working models of attachment [J].

Johnson, Susan C. ;

Dweck, Carol S. ;

Chen, Frances S. .

PSYCHOLOGICAL SCIENCE, 2007, 18 (06) :501-502

[29] Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking [J].

Kim, Heejung S. ;

Sherman, David K. ;

Sasaki, Joni Y. ;

Xu, Jun ;

Chu, Thai Q. ;

Ryu, Chorong ;

Suh, Eunkook M. ;

Graham, Kelsey ;

Taylor, Shelley E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (36) :15717-15721

[30] Oxytocin modulates neural circuitry for social cognition and fear in humans [J].

Kirsch, P ;

Esslinger, C ;

Chen, Q ;

Mier, D ;

Lis, S ;

Siddhanti, S ;

Gruppe, H ;

Mattay, VS ;

Gallhofer, B ;

Meyer-Lindenberg, A .

JOURNAL OF NEUROSCIENCE, 2005, 25 (49) :11489-11493

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