Oxytocin receptor (OXTR) polymorphisms and attachment in human infants

被引：82

作者：

Chen, Frances S. ^{[1
]}

Barth, Maria E. ^{[2
]}

Johnson, Stephen L. ^{[3
]}

Gotlib, Ian H. ^{[4
]}

Johnson, Susan C. ^{[5
]}

机构：

[1] Univ Freiburg, Dept Psychol, D-79104 Freiburg, Germany

[2] Tufts Univ, Dept Psychol, Boston, MA 02111 USA

[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[4] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA

[5] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA

来源：

FRONTIERS IN PSYCHOLOGY | 2011年 / 2卷

关键词：

attachment; trust; development; oxytocin; polymorphisms; GENE OXTR; STRESS REACTIVITY; SOCIAL COGNITION; ASSOCIATION; SENSITIVITY; INTERACT; DEFICITS; ANXIETY; AUTISM; ALLELE;

D O I：

10.3389/fpsyg.2011.00200

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Ordinary variations in human infants' attachment behaviors their proclivity to seek and accept comfort from caregivers are associated with a wide range of individual differences in psychological functioning in adults The current investigation examined variation in the oxytocin receptor (OXTR) gene as one possible source of these variations in infant attachment. One hundred seventy-six infants (77 Caucasian, 99 non Caucasian) were classified as securely or insecurely attached based on their behavior in the Strange Situation (Ainsworth et al., 1978). The A allele of OXTR rs2254298 was associated with attachment security in the non-Caucasian infants (p < 0.005). These findings underscore the importance of oxytocin in the development of human social behavior and support its role in social stress regulation and the development of trust.

引用

页数：6

共 51 条

[1]

Ainsworth S.M., 1978, PATTERNS ATTACHMENT

[2] Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting [J].

Bakermans-Kranenburg, Marian J. ;

van IJzendoorn, Marinus H. .

SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2008, 3 (02) :128-134

[3] Research Review: Genetic vulnerability or differential susceptibility in child development: the case of attachment [J].

Bakermans-Kranenburg, Marian J. ;

van IJzendoorn, Marinus H. .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2007, 48 (12) :1160-1173

[4] G x E interaction in the organization of attachment: mothers' responsiveness as a moderator of children's genotypes [J].

Barry, Robin A. ;

Kochanska, Grazyna ;

Philibert, Robert A. .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2008, 49 (12) :1313-1320

[5]

Bowlby J., 1982, ATTACHMENT LOSS VOL, V1

[6] Oxytocin enhances the experience of attachment security [J].

Buchheim, Anna ;

Heinrichs, Markus ;

George, Carol ;

Pokorny, Dan ;

Koops, Eva ;

Henningsen, Peter ;

O'Connor, Mary-Frances ;

Guendel, Harald .

PSYCHONEUROENDOCRINOLOGY, 2009, 34 (09) :1417-1422

[7]

Carlson EA, 1998, CHILD DEV, V69, P1107, DOI 10.2307/1132365

[8] Opinion - Gene-environment interactions in psychiatry: joining forces with neuroscience [J].

Caspi, Avshalom ;

Moffitt, Terrie E. .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (07) :583-590

[9] The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus [J].

Chang, FM ;

Kidd, JR ;

Livak, KJ ;

Pakstis, AJ ;

Kidd, KK .

HUMAN GENETICS, 1996, 98 (01) :91-101

[10] An Oxytocin Receptor Gene Variant Predicts Attachment Anxiety in Females and Autism-Spectrum Traits in Males [J].

Chen, Frances S. ;

Johnson, Susan C. .

SOCIAL PSYCHOLOGICAL AND PERSONALITY SCIENCE, 2012, 3 (01) :93-99

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