Synthesis, characterization, and pharmacological evaluation of 1-[2-(6-nitro-4-oxo-2-phenyl-4H-quinazolin-3-yl)-ethyl]-3-phenyl ureas

被引：9
|
作者：
Rana, Aniruddhasinh M. [1 ]
Desai, Kishor R. [2 ]
Jauhari, Smita [1 ]
机构：
[1] SVNIT, Dept Appl Chem, Surat, Gujarat, India
[2] CG Bhakta Inst Biotechnol, Bardoli, Gujarat, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 01期
关键词：
Quinazolin-4(3H)-one; Phenyl isocyanates; Antimicrobial activity; ANTIFUNGAL;
D O I：
10.1007/s00044-012-0004-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the present communication, a series based on 1-[2-(6-nitro-4-oxo-2-phenyl-4H-quinazolin-3-yl)-ethyl]-3- phenyl-urea have been synthesized by an efficient synthetic protocol. The synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR spectroscopy, ESI Mass spectrometry, and elemental analysis. The antibacterial and antifungal activity of the compounds were studied against selected strains (Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 11774, and Candida albicans ATCC 66027) by using Kirby Bauer disk diffusion technique and broth dilution technique. All the synthesized compounds showed good antifungal potency against strain C. albicans.
引用
收藏
页码：225 / 233
页数：9
相关论文
共 50 条
  • [21] Microwave assisted synthesis and antimicrobial activity of novel 1-[1/2-(1-Benzyl-1H-[1,2,3] triazol-4-ylmethoxy)-naphthalen-2/1-yl]-3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-propenones
    Ashok, Dongamanti
    Ganesh, Arram
    Lakshmi, Bommidi Vijaya
    Ravi, Sidda
    Ramesh, Banoth
    ORGANIC COMMUNICATIONS, 2015, 8 (02) : 24 - 35
  • [22] Synthesis, crystal structure and antimicrobial activity of 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives against phytopathogens
    Zhijiang Fan
    Jun Shi
    Na Luo
    Xiaoping Bao
    Molecular Diversity, 2019, 23 : 615 - 624
  • [23] Synthesis, crystal structure and antimicrobial activity of 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives against phytopathogens
    Fan, Zhijiang
    Shi, Jun
    Luo, Na
    Bao, Xiaoping
    MOLECULAR DIVERSITY, 2019, 23 (03) : 615 - 624
  • [24] Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1, 3-thiazol-2-yl]-1H-pyrazoles
    Abdel-Wahab, Bakr F.
    Abdel-Aziz, Hatem A.
    Ahmed, Essam M.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (06) : 2632 - 2635
  • [25] Solvent-free microwave assisted synthesis of substituted (E)-phenyl{3-(2-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]vinyl)benzofuran-2-yl}methanones and their antimicrobial activity
    Ashok, D.
    Ziauddin, M.
    Lakshmi, B. V.
    Sarasija, M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (04) : 857 - 862
  • [26] Synthesis and Antimicrobial Activity of 2-[2-(2,6-dichloro phenyl) amino] benzyl-3-(5-substituted phenyl-4,5-dihydro-1H-pyrazol-3-yl-amino)- 6,8-dibromoquinazolin-4(3H) ones
    Patel, N. B.
    Patel, J. C.
    Barat, G. G.
    JOURNAL OF YOUNG PHARMACISTS, 2010, 2 (02) : 173 - 182
  • [27] Synthesis of (E)-(4-(Aryl)phenyl)(3-(2-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)vinyl)benzofuran-2-yl) methanones by Claisen Schmidt-Suzuki Cross Coupling and their Antibacterial and Antifungal Activity
    Ashok, Dongamanti
    Ziauddin, Mohammad
    Lakshmi, Bommidi Vijaya
    Sarasija, Madderla
    JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, 2017, 61 (03) : 167 - 176
  • [28] Solvent-free microwave assisted synthesis of substituted (E)-phenyl{3-(2-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]vinyl)benzofuran-2-yl}methanones and their antimicrobial activity
    D. Ashok
    M. Ziauddin
    B. V. Lakshmi
    M. Sarasija
    Russian Journal of General Chemistry, 2017, 87 : 857 - 862
  • [29] Synthesis of 3-substituted phenacyl-5-[2-phenyl-4H-4-oxo-1-benzopyran-6-yl)methylenyl]-thiazolidine-2,4-diones and evaluation of their antimicrobial activity
    Ayhan-Kilcigil, G
    Altanlar, N
    ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2000, 50 (02): : 154 - 157
  • [30] Synthesis and Biological Activity of New Series of N-[3-(1H-1,2,3-Benzotriazol-1-yl)propyl]-2-(substituted Phenyl)-3-Chloro-4-Oxo-1-Azetidinecarboxamide
    Sharma, Ritu
    Samadhiya, Pushkal
    Srivastava, Savitri D.
    Srivastava, Santosh K.
    ACTA CHIMICA SLOVENICA, 2011, 58 (01) : 110 - 119
12345