Synthesis, characterization, and pharmacological evaluation of 1-[2-(6-nitro-4-oxo-2-phenyl-4H-quinazolin-3-yl)-ethyl]-3-phenyl ureas

被引：9

作者：

Rana, Aniruddhasinh M. ^{[1
]}

Desai, Kishor R. ^{[2
]}

Jauhari, Smita ^{[1
]}

机构：

[1] SVNIT, Dept Appl Chem, Surat, Gujarat, India

[2] CG Bhakta Inst Biotechnol, Bardoli, Gujarat, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 01期

关键词：

Quinazolin-4(3H)-one; Phenyl isocyanates; Antimicrobial activity; ANTIFUNGAL;

D O I：

10.1007/s00044-012-0004-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present communication, a series based on 1-[2-(6-nitro-4-oxo-2-phenyl-4H-quinazolin-3-yl)-ethyl]-3- phenyl-urea have been synthesized by an efficient synthetic protocol. The synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR spectroscopy, ESI Mass spectrometry, and elemental analysis. The antibacterial and antifungal activity of the compounds were studied against selected strains (Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 11774, and Candida albicans ATCC 66027) by using Kirby Bauer disk diffusion technique and broth dilution technique. All the synthesized compounds showed good antifungal potency against strain C. albicans.

引用

页码：225 / 233

页数：9

共 50 条

[1] Synthesis, characterization, and pharmacological evaluation of 1-[2-(6-nitro-4-oxo-2-phenyl-4H-quinazolin-3-yl)-ethyl]-3-phenyl ureas
Aniruddhasinh M. Rana
Kishor R. Desai
Smita Jauhari
Medicinal Chemistry Research, 2013, 22 : 225 - 233
[2] SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF 2-ACETAMIDO-4-(5-SUBSTITUTED-PHENYL-4H-[1,2,4]TRIAZOL-3-YL) METHYLTHIAZOLES
Lata
Bhardwaj, Bharti
Kushwaha, Khushbu
Jain, Subhash C.
HETEROCYCLIC LETTERS, 2015, 5 (02): : 195 - 203
[3] Synthesis, characterization and antimicrobial activity of ethyl 2-(3-formyl-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)-alkoxy-)phenyl)-4-methylthiazole-5-carboxylate derivatives
Malik, G. M.
Naik, Chirag G.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2015, 54 (08): : 1005 - 1010
[4] Synthesis and Biological Activity of Some 2-(2′-(Substituted Phenyl-4-thiazolidinone-3-yl)-1′3′-isoxazol-4-yl)aminoquinoline Derivatives
Ahirwar, Mukesh Kumar
Shrivastava, S. P.
E-JOURNAL OF CHEMISTRY, 2011, 8 (02) : 931 - 937
[5] Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones
Sharma, Deepika
Narasimhan, Balasubramanian
Kumar, Pradeep
Jalbout, Abraham
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (03) : 1119 - 1127
[6] Synthesis and anticancer activity of some novel diethyl {(chromonyl/pyrazolyl) [(4-oxo-2-phenyl-quinazolin-3(4H)-yl)amino]methyl}phosphonates
Assiri, Mohammed A.
Ali, Tarik E.
Ali, Mamdouh M.
Yahia, I. S.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2018, 193 (10) : 668 - 674
[7] Microwave-assisted synthesis of 1-{2-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones and their antimicrobial activity
Ashok, D.
Padmavati, K.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2016, 86 (04) : 907 - 914
[8] Microwave-assisted synthesis of 1-{2-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones and their antimicrobial activity
D. Ashok
K. Padmavati
Russian Journal of General Chemistry, 2016, 86 : 907 - 914
[9] Synthesis, antimicrobial and antioxidant activities of 2-oxo-6-phenyl-2-yl-4-(2′-phenyl-5′-substituted 1H-indol-3′-yl)-1,2-dihydro pyridin-3-carbonitriles and their derivatives
Saundane, Anand Raghunath
Manjunatha, Yarlakatti
ARABIAN JOURNAL OF CHEMISTRY, 2016, 9 : S501 - S509
[10] SYNTHESIS OF 2-(SUBSTITUTED PHENYL)-3-[5-(2-OXO-2H-CHROMEN-3-YL)-1,3,4-OXADIAZOL-2-YL]-1,3-THIAZOLIDIN-4-ONES WITH ANTIMICROBIAL ACTIVITY
Bhat, Mashooq A.
Al-Omar, Mohammed A.
Siddiqui, Nadeem
ACTA POLONIAE PHARMACEUTICA, 2011, 68 (02): : 295 - 299

← 1 2 3 4 5 →