Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

被引：8
|
作者：
Park, Jin-Chul [1 ]
Bae, Eun-Bin [2 ]
Kim, Se-Eun [3 ]
Kim, So-Yun [4 ]
Choi, Kyung-Hee [5 ]
Choi, Jae-Won [2 ]
Bae, Ji-Hyeon [2 ]
Ryu, Jae-Jun [1 ]
Huh, Jung-Bo [2 ]
机构：
[1] Korea Univ, Sch Med, Dept Dent, Seoul 02841, South Korea
[2] Pusan Natl Univ, Sch Dent, Dept Prosthodont, PLUS Project BK21, Yangsan 50612, South Korea
[3] Chonnam Natl Univ, Dept Vet Surg, Coll Vet Med, Gwangju 61186, South Korea
[4] Pusan Natl Univ, Sch Dent, Yangsan 50612, South Korea
[5] Cowellmedi Co Ltd, Tissue Biotech Inst, Busan 46986, South Korea
来源：
MATERIALS | 2016年 / 9卷 / 11期
关键词：
alloplast; bone substitutes; biphasic calcium phosphate; calcium pyrophosphate; rhBMP-2; MORPHOGENETIC PROTEIN-2; DENTAL IMPLANTS; HYDROXYAPATITE; AUGMENTATION; SUBSTITUTES; CERAMICS; DEFECTS; RHBMP-2; TISSUE; PYROPHOSPHATE;
D O I：
10.3390/ma9110954
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.
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页数：11
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