Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

被引：9

作者：

Park, Jin-Chul ^{[1
]}

Bae, Eun-Bin ^{[2
]}

Kim, Se-Eun ^{[3
]}

Kim, So-Yun ^{[4
]}

Choi, Kyung-Hee ^{[5
]}

Choi, Jae-Won ^{[2
]}

Bae, Ji-Hyeon ^{[2
]}

Ryu, Jae-Jun ^{[1
]}

Huh, Jung-Bo ^{[2
]}

机构：

[1] Korea Univ, Sch Med, Dept Dent, Seoul 02841, South Korea

[2] Pusan Natl Univ, Sch Dent, Dept Prosthodont, PLUS Project BK21, Yangsan 50612, South Korea

[3] Chonnam Natl Univ, Dept Vet Surg, Coll Vet Med, Gwangju 61186, South Korea

[4] Pusan Natl Univ, Sch Dent, Yangsan 50612, South Korea

[5] Cowellmedi Co Ltd, Tissue Biotech Inst, Busan 46986, South Korea

来源：

MATERIALS | 2016年 / 9卷 / 11期

关键词：

alloplast; bone substitutes; biphasic calcium phosphate; calcium pyrophosphate; rhBMP-2; MORPHOGENETIC PROTEIN-2; DENTAL IMPLANTS; HYDROXYAPATITE; AUGMENTATION; SUBSTITUTES; CERAMICS; DEFECTS; RHBMP-2; TISSUE; PYROPHOSPHATE;

D O I：

10.3390/ma9110954

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.

引用

页数：11

共 42 条

[1]

Alam MI, 2001, BIOMATERIALS, V22, P1643

[2]

Barralet J, 2000, J BIOMED MATER RES, V49, P176, DOI 10.1002/(SICI)1097-4636(200002)49:2<176::AID-JBM4>3.0.CO

[3]

2-8

[4]

Bauer TW, 2000, CLIN ORTHOP RELAT R, P10

[5] Comparative evaluation of different calcium phosphate-based bone graft granules an in vitro study with osteoblast-like cells [J].

Bernhardt, Anne ;

Lode, Anja ;

Peters, Fabian ;

Gelinsky, Michael .

CLINICAL ORAL IMPLANTS RESEARCH, 2013, 24 (04) :441-449

[6] De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation [J].

Boyne, PJ ;

Lilly, LC ;

Marx, RE ;

Moy, PK ;

Nevins, M ;

Spagnoli, DB ;

Triplett, RG .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2005, 63 (12) :1693-1707

[7] HISTOLOGIC EVALUATION OF PERIODONTAL IMPLANTS IN A BIOLOGICALLY CLOSED MODEL [J].

BYE, FL ;

KRAUSE, ME ;

REGEZI, JA ;

CAFFESSE, RG .

JOURNAL OF PERIODONTOLOGY, 1987, 58 (02) :110-114

[8] Study of In Vivo Biocompatibility and Dynamics of Replacement of Rat Shin Defect with Porous Granulated Bioceramic Materials [J].

Chissov, V. I. ;

Sviridova, I. K. ;

Sergeeva, N. S. ;

Frank, G. A. ;

Kirsanova, V. A. ;

Achmedova, S. A. ;

Reshetov, I. V. ;

Filjushin, M. M. ;

Barinov, S. M. ;

Fadeeva, I. V. ;

Komlev, V. S. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 146 (01) :139-143

[9]

Clavero Jaime, 2003, Clin Implant Dent Relat Res, V5, P154, DOI 10.1111/j.1708-8208.2003.tb00197.x

[10] Implant survival rates after maxillary sinus augmentation [J].

Del Fabbro, Massimo ;

Rosano, Gabriele ;

Taschieri, Silvio .

EUROPEAN JOURNAL OF ORAL SCIENCES, 2008, 116 (06) :497-506

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