Primary Ovarian Solid Pseudopapillary Neoplasm With CTNNB1 c.98C>G (p.S33C) Point Mutation

被引：14
作者：
Singh, Kamaljeet [1 ]
Patel, Nimesh [2 ]
Patil, Pallavi [2 ]
Paquette, Cherie [1 ]
Mathews, Cara A. [3 ]
Lawrence, W. Dwayne [1 ]
机构：
[1] Brown Univ, Women & Infants Hosp Rhode Isl, Alpert Med Sch, Dept Pathol & Lab Med, Providence, RI 02912 USA
[2] Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Dept Pathol & Lab Med, Providence, RI 02903 USA
[3] Women & Infants Hosp Rhode Isl, Program Womens Oncol, Providence, RI USA
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | 2018年 / 37卷 / 02期
基金：
美国国家卫生研究院; 英国惠康基金;
关键词：
Ovary; Solid papillary neoplasm; Catenin; Point mutation; Extrapancreatic; OF-THE-LITERATURE; MICROCYSTIC STROMAL TUMOR; BETA-CATENIN MUTATION; E-CADHERIN; GENE-EXPRESSION; CYSTIC TUMOR; PANCREAS; ORIGIN; MESOCOLON; PATHWAYS;
D O I：
10.1097/PGP.0000000000000396
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Ovary is one of the extrapancreatic sites of origin of solid pseudopapillary neoplasm (SPN). Only 9 cases of primary ovarian SPN, 1 with CTNNB1 mutation similar to pancreatic SPN, have been reported in the English literature. We describe the second case of ovarian SPN with confirmed CTNNB1 mutation. A 49-year-old postmenopausal woman presented with a 4.5 cm right ovarian mass. Ovarian mass showed histologic and immunohistochemical features of pancreatic SPN. The ovarian surface was intact and uninvolved. Ki-67 index was low (1%-5%). DNA sequencing of CTNNB1 exon 3 revealed c.98C>G (p.S33C), a well-characterized activating mutation. Our case adds to the growing body of evidence that primary ovarian SPN are phenotypically and genotypically similar to pancreatic SPN.
引用
收藏
页码：110 / 116
页数：7
相关论文
共 30 条
[11]  
He SQ, 2015, INT J CLIN EXP PATHO, V8, P8645
[12]   A solid pseudopapillary tumor arising from the greater omentum followed by multiple metastases with increasing malignant potential [J].
Hibi, T ;
Ojima, H ;
Sakamoto, Y ;
Kosuge, T ;
Shimada, K ;
Sano, T ;
Sakamoto, M ;
Kitajima, M ;
Yamasaki, S .
JOURNAL OF GASTROENTEROLOGY, 2006, 41 (03) :276-281
[13]   Microcystic Stromal Tumor A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations [J].
Irving, Julie A. ;
Lee, Cheng-Han ;
Yip, Stephen ;
Oliva, Esther ;
McCluggage, W. Glenn ;
Young, Robert H. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2015, 39 (10) :1420-1426
[14]  
ISHIKAWA O, 1990, AM J GASTROENTEROL, V85, P597
[15]  
KIM YI, 1990, CANCER-AM CANCER SOC, V65, P2740, DOI 10.1002/1097-0142(19900615)65:12<2740::AID-CNCR2820651223>3.0.CO
[16]  
2-0
[17]   β-catenin mutation in ovarian solid pseudopapillary neoplasm [J].
Kominami, Ayami ;
Fujino, Masahiko ;
Murakami, Hideki ;
Ito, Masafumi .
PATHOLOGY INTERNATIONAL, 2014, 64 (09) :460-464
[18]   Solid-pseudopapillary tumor of the pancreas:: its origin revisited [J].
Kosmahl, M ;
Seada, LS ;
Jänig, U ;
Harms, D ;
Klöppel, G .
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 2000, 436 (05) :473-480
[19]   Pancreatic analogue solid pseudopapillary neoplasm arising in the paratesticular location. The first case report [J].
Michal, Michal ;
Bulimbasic, Stela ;
Coric, Marijana ;
Sedivcova, Monika ;
Kazakov, Dmitry V. ;
Michal, Michael ;
Hes, Ondrej .
HUMAN PATHOLOGY, 2016, 56 :52-56
[20]   Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm of pancreas [J].
Park, Minhee ;
Kim, Minhyung ;
Hwang, Daehee ;
Park, Misun ;
Kim, Won Kyu ;
Kim, Sang Kyum ;
Shin, Jihye ;
Park, Eun Sung ;
Kang, Chang Moo ;
Paik, Young-Ki ;
Kim, Hoguen .
MODERN PATHOLOGY, 2014, 27 (04) :580-593
123