Muscle-Organ Crosstalk: Focus on Immunometabolism

被引：68

作者：

Bay, Marie Lund ^{[1
]}

Pedersen, Bente Klarlund ^{[1
]}

机构：

[1] Univ Copenhagen, Rigshosp, Ctr Inflammat & Metab, Ctr Phys Act Res CIM CFAS, Copenhagen, Denmark

来源：

FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷

关键词：

metabolism; cytokines; exercise; physical activity; diabetes; cancer; SKELETAL-MUSCLE; ADIPOSE-TISSUE; DISCOVERY CHALLENGES; GLUCOSE-HOMEOSTASIS; NEUROTROPHIC FACTOR; HIPPOCAMPAL BDNF; ENDOCRINE ORGAN; FAT OXIDATION; EXERCISE; MYOKINES;

D O I：

10.3389/fphys.2020.567881

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Skeletal muscle secretes several hundred myokines that facilitate communication from muscle to other organs, such as, adipose tissue, pancreas, liver, gut, and brain. The biological roles of myokines include effects on e.g., memory and learning, as well as glucose and lipid metabolism. The present minireview focuses on recent developments showing that exercise-induced myokines are involved in immunometabolism of importance for the control of e.g., tumor growth and chronic inflammation. In this review, immunometabolism is discussed as the non-immune related pathologies leading to an immune response and some degree of inflammation, which promotes metabolic abnormalities.

引用

页数：8

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