Genes that control longevity in Podospora anserina

被引：14

作者：

Rossignol, M ^{[1
]}

Silar, P ^{[1
]}

机构：

[1] CNRS,CTR MOL GENET,F-91198 GIF SUR YVETTE,FRANCE

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1996年 / 90卷 / 03期

关键词：

Podospora anserina; filamentous fungus; gene; senescence;

D O I：

10.1016/0047-6374(96)01766-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two genetic methods were used to estimate the number of genes that potentially modulate longevity in the filamentous fungus Podospora anserina. First, life span of strains carrying mutations selected on criteria unrelated to senescence was measured. Second, strains bearing random mutations were generated by insertional mutagenesis. Life span of these strains was then measured. Surprisingly, both methods lead to the conclusion that a large number of genes (between 600 and 3000) can modulate life span. Among, the mutations that affect longevity, 50% increase life span and 50% diminish it.

引用

页码：183 / 193

页数：11

共 29 条

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