Oxidative Stress at the Retinal Pigment Epithelium - Experimental Implications for Protection

被引：1
作者：
Zeitz, O. [1 ]
Berna-Thill, M. [1 ]
Bartsch, U. [1 ]
Strauss, O. [2 ]
Richard, G. [1 ]
机构：
[1] Univ Klinikum Hamburg Eppendorf, Klin & Poliklin Augenheilkunde, D-20246 Hamburg, Germany
[2] Klinikum Univ Regensburg, Klin & Poliklin Augenheilkunde, Expt Ophthalmol, Regensburg, Germany
来源：
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE | 2009年 / 226卷 / 01期
关键词：
Retina; Pharmacology; Pathology; FACTOR-H POLYMORPHISM; HUMAN RPE CELLS; MACULAR DEGENERATION; DIABETIC-RETINOPATHY; VITAMIN-C; ERYTHROPOIETIN; LIPOFUSCIN; VEGF; APOPTOSIS; DAMAGE;
D O I：
10.1055/s-2008-1027600
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Oxidative stress at the retinal pigment epithelium (RPE) is involved in the pathophysiology of age-related macula degeneration (ARMD). Observations on a clinical or laboratory level have revealed that supplementation of antioxidative scavengers failed in many cases. A potential therapeutic target is the cellular signal transduction cascade initiated by oxidative stress which results, e.g., in altered expression of pro- and antiagiogenic factors as well as induction of apoptosis. This review summarises the current literature on cellular effects of free radicals and deduces potential therapeutic approaches to protect the RPE from oxidative damage.
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收藏
页码：27 / 30
页数：4
相关论文
共 54 条
  • [21] Kannan R, 2006, MOL VIS, V12, P1649
  • [22] A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss - AREDS Report No. 8
    Kassoff, A
    Kassoff, J
    Buehler, J
    Eglow, M
    Kaufman, F
    Mehu, M
    Kieval, S
    Mairs, M
    Graig, B
    Quattrocchi, A
    Jones, D
    Locatelli, J
    Ruby, A
    Capone, A
    Garretson, B
    Hassan, T
    Trese, MT
    Williams, GA
    Regan, V
    Manatrey, P
    Streasick, P
    Szydlowski, L
    McIver, F
    Bridges, C
    Stanley, C
    Cumming, K
    Lewis, B
    Zajechowski, M
    Margherio, RR
    Cox, MS
    Camille, J
    Falk, R
    Siedlak, P
    Neubert, C
    Klein, ML
    Stout, JT
    O'Malley, A
    Lauer, AK
    Robertson, JE
    Wilson, DJ
    Beardsley, C
    Anderson, H
    Wallace, P
    Smith, G
    Howard, S
    Dreyer, RF
    Ma, C
    Chenoweth, RG
    Zilis, JD
    Johnson, M
    [J]. ARCHIVES OF OPHTHALMOLOGY, 2001, 119 (10) : 1417 - 1436
  • [23] Complement factor H polymorphism in age-related macular degeneration
    Klein, RJ
    Zeiss, C
    Chew, EY
    Tsai, JY
    Sackler, RS
    Haynes, C
    Henning, AK
    SanGiovanni, JP
    Mane, SM
    Mayne, ST
    Bracken, MB
    Ferris, FL
    Ott, J
    Barnstable, C
    Hoh, J
    [J]. SCIENCE, 2005, 308 (5720) : 385 - 389
  • [24] Knauer C, 2006, OPHTHALMOLOGE, V103, P735, DOI 10.1007/s00347-006-1411-y
  • [25] Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction
    Li, Xuesen
    Liu, Zhongbo
    Luo, Cheng
    Jia, Haiqun
    Sun, Lijuan
    Hou, Bei
    Shen, Weili
    Packer, Lester
    Cotman, Carl W.
    Liu, Jiankang
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2008, 44 (07) : 1465 - 1474
  • [26] Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stress
    Liang, FQ
    Green, L
    Wang, C
    Alssadi, R
    Godley, BF
    [J]. EXPERIMENTAL EYE RESEARCH, 2004, 78 (06) : 1069 - 1075
  • [27] Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
    Luibl, V
    Isas, JM
    Kayed, R
    Glabe, CG
    Langen, R
    Chen, J
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (02) : 378 - 385
  • [28] Erythropoietin and the hypoxic brain
    Marti, HH
    [J]. JOURNAL OF EXPERIMENTAL BIOLOGY, 2004, 207 (18) : 3233 - 3242
  • [29] The oviduct produces erythropoietin in an estrogen- and oxygen-dependent manner
    Masuda, S
    Kobayashi, T
    Chikuma, M
    Nagao, M
    Sasaki, R
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 278 (06): : E1038 - E1044
  • [30] Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
    Mukherjee, PK
    Marcheselli, VL
    Serhan, CN
    Bazan, NG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (22) : 8491 - 8496
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