Multidrug-resistant Acinetobacter baumannii outbreak: an investigation of the possible routes of transmission

被引：21
作者：
Cristina, M. L. [1 ]
Spagnolo, A. M. [1 ]
Cenderello, N. [2 ]
Fabbri, P. [2 ]
Sartini, M. [1 ]
Ottria, G. [1 ]
Orlando, P. [1 ]
机构：
[1] Univ Genoa, Dept Hlth Sci, I-16132 Genoa, Italy
[2] Galliera Hosp, Genoa, Italy
来源：
PUBLIC HEALTH | 2013年 / 127卷 / 04期
关键词：
Acinetobacter baumannii; Outbreak; Transmission; INTENSIVE-CARE-UNIT; RISK-FACTORS; ANTIMICROBIAL SUSCEPTIBILITY; BURN UNIT; EPIDEMIOLOGY; INFECTION;
D O I：
10.1016/j.puhe.2013.01.025
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objectives: To establish the possible sources and routes of transmission of a multidrug-resistant Acinetobacter baumannii outbreak involving 22 patients. Study design: Descriptive, retrospective study. Methods: An environmental investigation was undertaken, monitoring surfaces, air and water. Reconstruction of the spread of the infection took several factors into account such as intrahospital movements of patients and healthcare personnel, hospitalization of patients in the same ward and in chronologically compatible periods, and length of stay. A. baumannii clinical samples were typed using the Multilocus Sequence Typing scheme. Results: The outbreak originated from a patient admitted to the sub-intensive care unit, and the infection subsequently spread to other wards. The allelic profile proved to be the same for all the clinical isolates. Environmental monitoring yielded negative results for A. baumannii. Conclusions: The results suggest that this epidemic spread through cross-transmission involving healthcare workers. (C) 2013 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：386 / 391
页数：6
相关论文
共 32 条
[21]   Genotypic diversity of imipenem resistant isolates of Acinetobacter baumannii in Spain [J].
Oteo, Jesus ;
Garcia-Estebanez, Carmen ;
Miguelanez, Silvia ;
Campos, Jose ;
Marti, Sara ;
Vila, Jordi ;
Dominguez, M. Angeles ;
Docobo, Fernando ;
Larrosa, Nieves ;
Pascual, Alvaro ;
Pintado, Vicente ;
Coll, Pere .
JOURNAL OF INFECTION, 2007, 55 (03) :260-266
[22]   Acinetobacter baumannii:: Emergence of a successful pathogen [J].
Peleg, Anton Y. ;
Seifert, Harald ;
Paterson, David L. .
CLINICAL MICROBIOLOGY REVIEWS, 2008, 21 (03) :538-582
[23]   Global challenge of multidrug-resistant Acinetobacter baumannii [J].
Perez, Federico ;
Hujer, Andrea M. ;
Hujer, Kristine M. ;
Decker, Brooke K. ;
Rather, Philip N. ;
Bonomo, Robert A. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (10) :3471-3484
[24]   An outbreak due to multiresistant Acinetobacter baumannii a burn unit:: Risk factors for acquisition and management [J].
Simor, AE ;
Vearncombe, M ;
Jones-Paul, L ;
Barry, C ;
Gomez, M ;
Fish, JS ;
Cartotto, RC ;
Palmer, R ;
Louie, M .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2002, 23 (05) :261-267
[25]   Hospital outbreak caused by a carbapenem-resistant strain of Acinetobacter baumannii:: patient prognosis and risk-factors for colonisation and infection [J].
Tomas, MD ;
Cartelle, M ;
Pertega, S ;
Beceiro, A ;
Llinares, P ;
Canle, D ;
Molina, F ;
Villanueva, R ;
Cisneros, JM ;
Bou, G .
CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (07) :540-546
[26]   Outbreak of Acinetobacter baumannii in a Neonatal Intensive Care Unit: Antimicrobial Susceptibility and Genotyping Analysis [J].
Touati, Arabella ;
Achour, Wafa ;
Cherif, Ahmed ;
Ben Hmida, Hayet ;
Aft, Firas Bou ;
Jabnoun, Sami ;
Khrouf, Naima ;
Ben Hassen, Assia .
ANNALS OF EPIDEMIOLOGY, 2009, 19 (06) :372-378
[27]   Acinetobacter: an old friend, but a new enemy [J].
Towner, K. J. .
JOURNAL OF HOSPITAL INFECTION, 2009, 73 (04) :355-363
[28]   Acinetobacter outbreaks, 1977-2000 [J].
Villegas, MV ;
Hartstein, AI .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2003, 24 (04) :284-295
[29]   Outbreak of nosocomial meningitis caused by Acinetobacter baumannii in neurosurgical patients [J].
Wroblewska, MM ;
Dijkshoorn, L ;
Marchel, H ;
van den Barselaar, M ;
Swoboda-Kopec, E ;
van den Broek, PJ ;
Luczak, M .
JOURNAL OF HOSPITAL INFECTION, 2004, 57 (04) :300-307
[30]   Outbreak of multidrug-resistant Acinetobacter boumannii in a Belgian university hospital after transfer of patients from Greece [J].
Wybo, I. ;
Blommaert, L. ;
De Beer, T. ;
Soetens, O. ;
De Regt, J. ;
Lacor, P. ;
Pierard, D. ;
Lauwers, S. .
JOURNAL OF HOSPITAL INFECTION, 2007, 67 (04) :374-380
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