When Immune Cells Turn Bad-Tumor-Associated Microglia/Macrophages in Glioma

被引：235

作者：

Roesch, Saskia ^{[1
]}

Rapp, Carmen ^{[1
]}

Dettling, Steffen ^{[1
]}

Herold-Mende, Christel ^{[1
]}

机构：

[1] Univ Hosp Heidelberg, Div Expt Neurosurg, Dept Neurosurg, INF400, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 02期

关键词：

microglia; glioma-associated microglia; macrophages; GAMs; glioma; glioblastoma; GBM; tumor microenvironment; TME; EPIDERMAL-GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; CHEMOATTRACTANT PROTEIN-1 MCP-1; STRESS-INDUCIBLE PROTEIN-1; MHC CLASS-II; MICROGLIAL CELLS; FACTOR RECEPTOR; FACTOR-BETA; IN-VITRO; DIFFERENTIAL EXPRESSION;

D O I：

10.3390/ijms19020436

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role regarding glioma cell invasion and angiogenesis. Finally, we summarize first therapeutic interventions to target GAMs and their effect on the immunobiology of gliomas, focusing on their interaction with T cells.

引用

页数：20

共 167 条

[1] The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas [J].

Abou-Ghazal, Mohamed ;

Yang, David S. ;

Qiao, Wei ;

Reina-Ortiz, Chantal ;

Wei, Jun ;

Kong, Ling-Yuan ;

Fuller, Gregory N. ;

Hiraoka, Nobuyoshi ;

Priebe, Waldemar ;

Sawaya, Raymond ;

Heimberger, Amy B. .

CLINICAL CANCER RESEARCH, 2008, 14 (24) :8228-8235

[2] Flow cytometric characterization of tumor-associated macrophages in experimental gliomas [J].

Badie, B ;

Schartner, JM .

NEUROSURGERY, 2000, 46 (04) :957-961

[3] Differential expression of MHC class II and B7 costimulatory molecules by microglia in rodent gliomas [J].

Badie, B ;

Bartley, B ;

Schartner, J .

JOURNAL OF NEUROIMMUNOLOGY, 2002, 133 (1-2) :39-45

[4] Expression of Fas ligand by microglia: possible role in glioma immune evasion [J].

Badie, B ;

Schartner, J ;

Prabakaran, S ;

Paul, J ;

Vorpahl, J .

JOURNAL OF NEUROIMMUNOLOGY, 2001, 120 (1-2) :19-24

[5] Time Lapse In Vivo Microscopy Reveals Distinct Dynamics of Microglia-Tumor Environment Interactions-A New Role for the Tumor Perivascular Space as Highway for Trafficking Microglia [J].

Bayerl, Simon Heinrich ;

Niesner, Raluca ;

Cseresnyes, Zoltan ;

Radbruch, Helena ;

Pohlan, Julian ;

Brandenburg, Susan ;

Czabanka, Marcus Alexander ;

Vajkoczy, Peter .

GLIA, 2016, 64 (07) :1210-1226

[6] New tools for studying microglia in the mouse and human CNS [J].

Bennett, Mariko L. ;

Bennett, F. Chris ;

Liddelow, Shane A. ;

Ajami, Bahareh ;

Zamanian, Jennifer L. ;

Fernhoff, Nathaniel B. ;

Mulinyawe, Sara B. ;

Bohlen, Christopher J. ;

Adil, Aykezar ;

Tucker, Andrew ;

Weissman, Irving L. ;

Chang, Edward F. ;

Li, Gordon ;

Grant, Gerald A. ;

Gephart, Melanie G. Hayden ;

Barres, Ben A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (12) :E1738-E1746

[7] Microglia promote glioma migration [J].

Bettinger, I ;

Thanos, S ;

Paulus, W .

ACTA NEUROPATHOLOGICA, 2002, 103 (04) :351-355

[8] IMMORTALIZATION OF MURINE MICROGLIAL CELLS BY A V-RAF/V-MYC CARRYING RETROVIRUS [J].

BLASI, E ;

BARLUZZI, R ;

BOCCHINI, V ;

MAZZOLLA, R ;

BISTONI, F .

JOURNAL OF NEUROIMMUNOLOGY, 1990, 27 (2-3) :229-237

[9] Review: Activation patterns of microglia and their identification in the human brain [J].

Boche, D. ;

Perry, V. H. ;

Nicoll, J. A. R. .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2013, 39 (01) :3-18

[10]

BODMER S, 1989, J IMMUNOL, V143, P3222

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