Human Th17 cells in patients with cancer Friends or foe?

被引：15

作者：

Greten, Tim F. ^{[1
]}

Zhao, Fei ^{[1
]}

Gamrekelashvili, Jaba ^{[1
]}

Korangy, Firouzeh ^{[1
]}

机构：

[1] NCI, Gastrointestinal Malignancy Sect, Med Oncol Branch, Bethesda, MD 20892 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 08期

关键词：

IL-17; CCR4; CCR6; liver; cancer; HEPATOCELLULAR-CARCINOMA;

D O I：

10.4161/onci.21245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+) CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions in vitro. These results suggest that Th17 cells may exert immunosuppressive functions in hepatocellular carcinoma.

引用

页码：1438 / 1439

页数：2

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