Flu Universal Vaccines: New Tricks on an Old Virus

被引：15
作者：
Du, Ruikun [1 ,2 ,3 ]
Cui, Qinghua [1 ,2 ,3 ]
Rong, Lijun [4 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266122, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China
[4] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA
来源：
VIROLOGICA SINICA | 2021年 / 36卷 / 01期
关键词：
Influenza virus; Universal vaccine; Conserved epitopes; Broadly protection; INFLUENZA-A VIRUS; DEPENDENT CELLULAR CYTOTOXICITY; HEMAGGLUTININ STALK ANTIBODIES; ANTI-NEURAMINIDASE ANTIBODY; M2; PROTEIN; MONOCLONAL-ANTIBODY; GLOBULAR HEAD; PANDEMIC H1N1; NEUTRALIZING EPITOPE; PROTECTION;
D O I：
10.1007/s12250-020-00283-6
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protection against pan-influenza viruses. The discovery of the highly conserved immunogens (epitopes) of influenza viruses provides attractive targets for universal vaccine design. Here we review the current understanding with broadly protective immunogens (epitopes) and discuss several important considerations to achieve the goal of universal influenza vaccines.
引用
收藏
页码：13 / 24
页数：12
相关论文
共 50 条
  • [41] Porcine Reproductive and Respiratory Syndrome Virus Vaccines: Current Status and Strategies to a Universal Vaccine
    Hu, J.
    Zhang, C.
    TRANSBOUNDARY AND EMERGING DISEASES, 2014, 61 (02) : 109 - 120
  • [42] Progress on adenovirus-vectored universal influenza vaccines
    Kui Xiang
    Guan Ying
    Zhou Yan
    Yan Shanshan
    Zhang Lei
    Li Hongjun
    Sun Maosheng
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2015, 11 (05) : 1209 - 1222
  • [43] Influenza virus hemagglutinin stalk-based antibodies and vaccines
    Krammer, Florian
    Palese, Peter
    CURRENT OPINION IN VIROLOGY, 2013, 3 (05) : 521 - 530
  • [44] M2e-based universal influenza vaccines: a historical overview and new approaches to development
    Mezhenskaya, Daria
    Isakova-Sivak, Irina
    Rudenko, Larisa
    JOURNAL OF BIOMEDICAL SCIENCE, 2019, 26 (01)
  • [45] Nonneutralizing Functional Antibodies: a New "Old" Paradigm for HIV Vaccines
    Excler, Jean-Louis
    Ake, Julie
    Robb, Merlin L.
    Kim, Jerome H.
    Plotkin, Stanley A.
    CLINICAL AND VACCINE IMMUNOLOGY, 2014, 21 (08) : 1023 - 1036
  • [46] Re-thinking yellow fever vaccines: fighting old foes with new generation vaccines
    Montalvo Zurbia-Flores, Gerardo
    Rollier, Christine S.
    Reyes-Sandoval, Arturo
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2022, 18 (01)
  • [47] Searching for Improved Flu Vaccines-The Time Is Now
    Atmar, Robert L.
    Keitel, Wendy A.
    JOURNAL OF INFECTIOUS DISEASES, 2020, 221 (01) : 1 - 4
  • [48] Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments
    Schotsaert, Michael
    De Filette, Marina
    Fiers, Walter
    Saelens, Xavier
    EXPERT REVIEW OF VACCINES, 2009, 8 (04) : 499 - 508
  • [49] Emerging influenza viruses and the prospect of a universal influenza virus vaccine
    Krammer, Florian
    BIOTECHNOLOGY JOURNAL, 2015, 10 (05) : 690 - U70
  • [50] A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies
    Sunwoo, Sun-Young
    Schotsaert, Michael
    Morozov, Igor
    Davis, Anne Sally
    Li, Yuhao
    Lee, Jinhwa
    McDowell, Chester
    Meade, Philip
    Nachbagauer, Raffael
    Garcia-Sastre, Adolfo
    Ma, Wenjun
    Krammer, Florian
    Richt, Juergen A.
    VACCINES, 2018, 6 (03):
12345