Flu Universal Vaccines: New Tricks on an Old Virus

被引：15
作者：
Du, Ruikun [1 ,2 ,3 ]
Cui, Qinghua [1 ,2 ,3 ]
Rong, Lijun [4 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266122, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China
[4] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA
来源：
VIROLOGICA SINICA | 2021年 / 36卷 / 01期
关键词：
Influenza virus; Universal vaccine; Conserved epitopes; Broadly protection; INFLUENZA-A VIRUS; DEPENDENT CELLULAR CYTOTOXICITY; HEMAGGLUTININ STALK ANTIBODIES; ANTI-NEURAMINIDASE ANTIBODY; M2; PROTEIN; MONOCLONAL-ANTIBODY; GLOBULAR HEAD; PANDEMIC H1N1; NEUTRALIZING EPITOPE; PROTECTION;
D O I：
10.1007/s12250-020-00283-6
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protection against pan-influenza viruses. The discovery of the highly conserved immunogens (epitopes) of influenza viruses provides attractive targets for universal vaccine design. Here we review the current understanding with broadly protective immunogens (epitopes) and discuss several important considerations to achieve the goal of universal influenza vaccines.
引用
收藏
页码：13 / 24
页数：12
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