Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis

被引：179

作者：

Park, Sang-Wook ^{[1
]}

Li, Wei ^{[2
]}

Viehhauser, Andrea ^{[3
]}

He, Bin ^{[4
]}

Kim, Soonok ^{[5
]}

Nilsson, Anders K. ^{[6
]}

Andersson, Mats X. ^{[6
]}

Kittle, Joshua D. ^{[7
]}

Ambavaram, Madana M. R. ^{[1
]}

Luan, Sheng ^{[8
]}

Esker, Alan R. ^{[7
]}

Tholl, Dorothea ^{[4
]}

Cimini, Daniela ^{[4
]}

Ellerstrom, Mats ^{[6
]}

Coaker, Gitta ^{[2
]}

Mitchell, Thomas K. ^{[5
]}

Pereira, Andy ^{[1
]}

Dietz, Karl-Josef ^{[3
]}

Lawrence, Christopher B. ^{[1
,4
]}

机构：

[1] Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA

[2] Univ Calif Davis, Dept Plant Pathol, Davis, CA 95616 USA

[3] Univ Bielefeld, D-33501 Bielefeld, Germany

[4] Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA

[5] Ohio State Univ, Dept Plant Pathol, Columbus, OH 43210 USA

[6] Univ Gothenburg, Dept Biol & Environm Sci, SE-40530 Gothenburg, Sweden

[7] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[8] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 23期

基金：

美国国家科学基金会;

关键词：

wounding; cysteine biosynthesis; GSH; TGA; plant plasticity; TGA TRANSCRIPTION FACTORS; JASMONIC ACID; GENE-EXPRESSION; SALICYLIC-ACID; DEFENSE; PLAYS; BIOSYNTHESIS; INDUCTION; COMPLEX; LIGHT;

D O I：

10.1073/pnas.1218872110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The jasmonate family of phytohormones plays central roles in plant development and stress acclimation. However, the architecture of their signaling circuits remains largely unknown. Here we describe a jasmonate family binding protein, cyclophilin 20-3 (CYP20-3), which regulates stress-responsive cellular redox homeostasis. (+)-12-oxo-phytodienoic acid (OPDA) binding promotes CYP20-3 to form a complex with serine acetyltransferase 1, which triggers the formation of a hetero-oligomeric cysteine synthase complex with O-acetylserine (thiol) lyase B in chloroplasts. The cysteine synthase complex formation then activates sulfur assimilation that leads to increased levels of thiol metabolites and the buildup of cellular reduction potential. The enhanced redox capacity in turn coordinates the expression of a subset of OPDA-responsive genes. Thus, we conclude that CYP20-3 is a key effector protein that links OPDA signaling to amino acid biosynthesis and cellular redox homeostasis in stress responses.

引用

页码：9559 / 9564

页数：6

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