Diterpenes from the Roots of Oryza sativa L. and Their Inhibition Activity on NO Production in LPS-Stimulated RAW264.7 Macrophages

被引：19

作者：

Cho, Jin-Gyeong ^{[1
,2
]}

Cha, Byeong-Ju ^{[1
,2
]}

Lee, Sang Min ^{[1
,2
]}

Shrestha, Sabina ^{[1
,2
]}

Jeong, Rak-Hun ^{[1
,2
]}

Lee, Dong Sung ^{[3
]}

Kim, Youn-Chul ^{[3
]}

Lee, Dong-Geol ^{[4
]}

Kang, Hee-Cheol ^{[4
]}

Kim, Jiyoung ^{[1
,2
]}

Baek, Nam-In ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Grad Sch Biotechnol, Yongin 446701, South Korea

[2] Kyung Hee Univ, Res Inst Life Sci & Resources, Yongin 446701, South Korea

[3] Won Kwang Univ, Coll Pharm, Standardized Mat Bank New Bot Drugs, Iksan 570749, South Korea

[4] GFC Co Ltd, R&D Ctr, Suwon 443813, South Korea

来源：

CHEMISTRY & BIODIVERSITY | 2015年 / 12卷 / 09期

关键词：

RAW; 264.7; RICE; MOMILACTONE;

D O I：

10.1002/cbdv.201400239

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new pimarane diterpenoids, momilactone D (3) and momilactone E (5), along with three known diterpenoids, momilactone A (1), sandaracopimaradien-3-one (2), and oryzalexin A (4) were isolated from Oryza sativa roots. The chemical structures of the compounds were determined by spectroscopic data analysis. The isolated diterpenoids were evaluated for their ability to inhibit NO production and iNOS mRNA and protein expression in LPS-stimulated RAW264.7 macrophages. Compound 4 showed strong inhibition activity on NO production, and compounds 1 and 4 decreased the expression of iNOS mRNA and protein levels.

引用

页码：1356 / 1364

页数：9

共 9 条

[1] Inhibitory Effects of an Ethyl Acetate Fraction from Cephalonoplos segetum on Inflammatory Mediators from Lipopolysaccharide-induced RAW 264.7 Macrophages
Chun, Jin Mi
Cheon, Myeong Sook
Park, Mikyung
Lee, A. Yeong
Moon, Byeong Cheol
Ji, Yunui
Kim, Ho Kyoung
[J]. JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, 2012, 55 (01): : 41 - 46
[2] Identification of a Degradation Intermediate of the Momilactone A Rice Phytoalexin by the Rice Blast Fungus
Imai, Takuya
Ohashi, Yuko
Mitsuhara, Ichiro
Seo, Shigemi
Toshima, Hiroaki
Hasegawa, Morifumi
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2012, 76 (02) : 414 - 416
[3] Allelopathic substance in rice root exudates: Rediscovery of momilactone B as an allelochemical
Kato-Noguchi, H
[J]. JOURNAL OF PLANT PHYSIOLOGY, 2004, 161 (03) : 271 - 276
[4] Kato-Noguchi H, 2008, JPN J PLANT SCI, V2, P18
[5] Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships
Kim, HK
Cheon, BS
Kim, YH
Kim, SY
Kim, HP
[J]. BIOCHEMICAL PHARMACOLOGY, 1999, 58 (05) : 759 - 765
[6] KONO Y, 1985, AGR BIOL CHEM TOKYO, V49, P1695
[7] Lee TH, 2007, MOL CELLS, V23, P398
[8] Okono Y., 2007, NAT PROD RES, V21, P305
[9] A Study on the Lipid Components of Rice in Relation to Palatability and Storage
Yoon, Mi-Ra
Rico, Catherine W.
Koh, Hee-Jong
Kang, Mi-Young
[J]. JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, 2012, 55 (04): : 515 - 521

← 1 →