SCID mouse models to study human cancer pathogenesis and approaches to therapy: Potential, limitations, and future directions

被引：22

作者：

Bankert, RB ^{[1
]}

Hess, SD ^{[1
]}

Egilmez, NK ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Microbiol, Buffalo, NY 14214 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2002年 / 7卷

关键词：

cancer therapy; immunotherapy; human cancer; SCID mouse; chimeric animal models; human-tumor xenografts; drug delivery; cytokines; cancer vaccines; review;

D O I：

10.2741/bankert

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The successful engraftment of human tumors and human immunocompetent cells into severe combined immunodeficient (SCID) mice has led to the generation of a wide array of different experimental designs that have proven useful in studying the cell biology of human cancer, and for evaluating novel therapeutic approaches to the treatment of cancer. In this review five of the most frequently used embodiments of the SCID model are presented. The goals of this review are to discuss how each model has been utilized to study human cancer and its response to many different novel therapies, to provide an assessment of the strengths and limitations of each model, and to outline future directions with a focus on what is needed to overcome some of the current limitations and pitfalls of the SCID models.

引用

页码：C44 / C62

页数：19

共 188 条

[1] The CXC chemokine, monokine induced by interferon-γ, inhibits non-small cell lung carcinoma tumor growth and metastasis [J].