A cellular based model of the colon crypt suggests novel effects for Apc phenotype in colorectal carcinogenesis

被引：5
作者：
Ingham-Dempster, Tim [1 ,2 ]
Corfe, Bernard [1 ,2 ]
Walker, Dawn [1 ,3 ]
机构：
[1] Univ Sheffield, INSIGNEO Inst, Sheffield, S Yorkshire, England
[2] Univ Sheffield, Dept Oncol & Metab, Mol Gastroenterol Res Grp, Sheffield, S Yorkshire, England
[3] Univ Sheffield, Dept Comp Sci, Sheffield, S Yorkshire, England
来源：
JOURNAL OF COMPUTATIONAL SCIENCE | 2018年 / 24卷
关键词：
Agent based modelling; Colon crypt; Apc loss; MONOCLONAL CONVERSION; EPITHELIUM; MIGRATION; DIFFERENTIATION; PROLIFERATION; ORGANIZATION; NUMBERS; DEATH; CELLS;
D O I：
10.1016/j.jocs.2017.06.013
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
Colorectal cancer (CRC) is a major cause of cancer mortality; loss of the Apc gene is an early step in the formation of CRC. A new computational model of the colonic crypt has been developed to simulate the effects of Apc loss. The model includes a region of flat mucosa, which has not previously been considered in the context of Apc loss. The model suggests that Apc loss confers a survival advantage at the crypt mouth which may be a previously unknown method of mutation fixation. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：125 / 131
页数：7
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