Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders

被引：254

作者：

Kelesidis, Theodoros ^{[2
]}

Pothoulakis, Charalabos ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Inflammatory Bowel Dis, Div Digest Dis, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Infect Dis, Los Angeles, CA 90095 USA

来源：

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2012年 / 5卷 / 02期

关键词：

efficacy; gastrointestinal disorders; probiotic; Saccharomyces boulardii; safety; CLOSTRIDIUM-DIFFICILE TOXIN; ANTIBIOTIC-ASSOCIATED DIARRHEA; HELICOBACTER-PYLORI THERAPY; IRRITABLE-BOWEL-SYNDROME; RAT SMALL-INTESTINE; ESCHERICHIA-COLI; BACTERIAL TRANSLOCATION; SALMONELLA-TYPHIMURIUM; ACUTE GASTROENTERITIS; ENDOLUMINAL RELEASE;

D O I：

10.1177/1756283X11428502

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Several clinical trials and experimental studies strongly suggest a place for Saccharomyces boulardii as a biotherapeutic agent for the prevention and treatment of several gastrointestinal diseases. S. boulardii mediates responses resembling the protective effects of the normal healthy gut flora. The multiple mechanisms of action of S. boulardii and its properties may explain its efficacy and beneficial effects in acute and chronic gastrointestinal diseases that have been confirmed by clinical trials. Caution should be taken in patients with risk factors for adverse events. This review discusses the evidence for efficacy and safety of S. boulardii as a probiotic for the prevention and therapy of gastrointestinal disorders in humans.

引用

页码：111 / 125

页数：15

共 133 条

[1]

Barc MC, 2008, ANAEROBE, V14, P229, DOI 10.1016/j.anaerobe.2008.04.003

[2] Antibiotic-associated diarrhea [J].

Bartlett, JG .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (05) :334-339

[3]

Bennani A., 1990, OBJECTIF MEDICAL, V73, P56

[4] Saccharomyces boulardii and infection due to Giardia lamblia [J].

Besirbellioglu, Bulent A. ;

Ulcay, Asim ;

Can, Mehmet ;

Erdem, Hakan ;

Tanyuksel, Mehmet ;

Avci, Ismail Yasar ;

Araz, Engin ;

Pahsa, Alaaddin .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2006, 38 (6-7) :479-481

[5] Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea [J].

Billoo, A. G. ;

Memon, M. A. ;

Khaskheli, S. A. ;

Murtaza, G. ;

Iqbal, Khalid ;

Shekhani, M. Saeed ;

Siddiqi, Ahson Q. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (28) :4557-4560

[6] Preventive Effects of Different Probiotic Formulations on Travelers' Diarrhea Model in Wistar Rats Preventive Effects of Probiotics on TD [J].

Bisson, Jean-Francois ;

Hidalgo, Sophie ;

Rozan, Pascale ;

Messaoudi, Michael .

DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (04) :911-919

[7] DISPOSITION KINETICS OF SACCHAROMYCES-BOULARDII IN MAN AND RAT [J].

BLEHAUT, H ;

MASSOT, J ;

ELMER, GW ;

LEVY, RH .

BIOPHARMACEUTICS & DRUG DISPOSITION, 1989, 10 (04) :353-364

[8] Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients - A multicenter, randomized, double-blind placebo-controlled trial [J].

Bleichner, G ;

Blehaut, H ;

Mentec, H ;

Moyse, D .

INTENSIVE CARE MEDICINE, 1997, 23 (05) :517-523

[9]

Brandao RL, 1998, APPL ENVIRON MICROB, V64, P564

[10] Application of the colon-simulation technique for studying the effects of Saccharomyces boulardii on basic parameters of porcine cecal microbial metabolism disturbed by clindamycin [J].

Breves, G ;

Faul, K ;

Schröder, B ;

Holst, H ;

Caspary, WF ;

Stein, JG .

DIGESTION, 2000, 61 (03) :193-200

← 1 2 3 4 5 6 7 8 9 10 →