Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders

被引：240
|
作者：
Kelesidis, Theodoros [2 ]
Pothoulakis, Charalabos [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Inflammatory Bowel Dis, Div Digest Dis, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Infect Dis, Los Angeles, CA 90095 USA
来源：
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2012年 / 5卷 / 02期
关键词：
efficacy; gastrointestinal disorders; probiotic; Saccharomyces boulardii; safety; CLOSTRIDIUM-DIFFICILE TOXIN; ANTIBIOTIC-ASSOCIATED DIARRHEA; HELICOBACTER-PYLORI THERAPY; IRRITABLE-BOWEL-SYNDROME; RAT SMALL-INTESTINE; ESCHERICHIA-COLI; BACTERIAL TRANSLOCATION; SALMONELLA-TYPHIMURIUM; ACUTE GASTROENTERITIS; ENDOLUMINAL RELEASE;
D O I：
10.1177/1756283X11428502
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Several clinical trials and experimental studies strongly suggest a place for Saccharomyces boulardii as a biotherapeutic agent for the prevention and treatment of several gastrointestinal diseases. S. boulardii mediates responses resembling the protective effects of the normal healthy gut flora. The multiple mechanisms of action of S. boulardii and its properties may explain its efficacy and beneficial effects in acute and chronic gastrointestinal diseases that have been confirmed by clinical trials. Caution should be taken in patients with risk factors for adverse events. This review discusses the evidence for efficacy and safety of S. boulardii as a probiotic for the prevention and therapy of gastrointestinal disorders in humans.
引用
收藏
页码：111 / 125
页数：15
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