Effects of primaquine and chloroquine on oxidative stress parameters in rats

被引：20

作者：

Giovanella, Francianne ^{[1
,2
,3
]}

Ferreira, Gabriela K. ^{[1
,2
,3
]}

De Pra, Samira D. T. ^{[1
,2
,3
]}

Carvalho-Silva, Milena ^{[1
,2
,3
]}

Gomes, Lara M. ^{[1
,2
,3
]}

Scaini, Giselli ^{[1
,2
,3
]}

Goncalves, Renata C. ^{[2
,4
]}

Michels, Monique ^{[2
,4
]}

Galant, Leticia S. ^{[2
,4
]}

Longareti, Luiza M. ^{[5
]}

Dajori, Ana Luiza ^{[5
]}

Andrade, Vanesa M. ^{[5
]}

Dal-Pizzol, Felipe ^{[2
,4
]}

Streck, Emilio L. ^{[1
,2
,3
]}

De Souza, Renan P. ^{[6
]}

机构：

[1] Univ Extremo Sul Catarinense, Lab Bioenerget, BR-88806000 Criciuma, SC, Brazil

[2] Inst Nacl Ciencia & Tecnol Translac Med, BR-90035903 Porto Alegre, RS, Brazil

[3] NENASC, BR-88806000 Criciuma, SC, Brazil

[4] Univ Extremo Sul Catarinense, Lab Fisiopatol Expt, Programa Posgrad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil

[5] Univ Extremo Sul Catarinense, Lab Biol Celular & Mol, Programa Posgrad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil

[6] Univ Fed Minas Gerais, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2015年 / 87卷 / 02期

关键词：

primaquine; chloroquine; oxidative damage; DNA damage; antimalarial drugs; HEPATIC-MICROSOMAL COMPONENTS; INDUCED HEMOLYTIC-ANEMIA; PLASMODIUM-FALCIPARUM; LIPID-PEROXIDATION; DNA-DAMAGE; MALARIA CHEMOTHERAPY; IN-VITRO; DRUG; RESISTANCE; CELLS;

D O I：

10.1590/0001-3765201520140637

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in the kidney after 7 days, and decreases TBARS levels in the brain after 21 days. Moreover, decreases protein carbonyls in the liver after 7 and 14 days, and in the brain after 7 and 21 days. However, chloroquine treatment for 14 days increases protein carbonyls in the brain and kidney. In conclusion, these results showed that prolonged treatment with antimalarial may adversely affect the DNA.

引用

页码：1487 / 1496

页数：10

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