Gut-Busters: IL-17 Ain't Afraid of No IL-23

被引：49

作者：

Whibley, Natasha ^{[1
]}

Gaffen, Sarah L. ^{[2
]}

机构：

[1] Univ Oxford, Kennedy Inst Rheumatol, Oxford OX3 7FY, England

[2] Univ Pittsburgh, Dept Med, Div Rheumatol & Clin Immunol, 930 Scaife Hall, Pittsburgh, PA 15261 USA

来源：

IMMUNITY | 2015年 / 43卷 / 04期

关键词：

INTERLEUKIN-17; INFLAMMATION; COLITIS;

D O I：

10.1016/j.immuni.2015.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, helping explain this dichotomy (Lee et al., 2015; Maxwell et al., 2015).

引用

页码：620 / 622

页数：3

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