Impact of Artemisinin-Based Combination Therapy on Falciparum Malaria in Urban Kolkata: A Clinic-Based Report

被引：2

作者：

Saha, Pabitra ^{[1
]}

Ganguly, Swagata ^{[1
]}

Dutta, Soma ^{[1
]}

Kundu, Pratip K. ^{[1
]}

Bera, Dilip K. ^{[1
]}

Basu, Nandita ^{[2
]}

Maji, Ardhendu K. ^{[1
]}

机构：

[1] Calcutta Sch Trop Med, Dept Microbiol, Kolkata 700073, India

[2] Calcutta Sch Trop Med, Kolkata 700073, India

来源：

JAPANESE JOURNAL OF INFECTIOUS DISEASES | 2015年 / 68卷 / 04期

关键词：

PLASMODIUM-FALCIPARUM; VIVAX MALARIA; INDIA; EFFICACY;

D O I：

10.7883/yoken.JJID.2014.284

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In India, artemisinin-based combination therapy (ACT; specifically artesunate + sulfadoxine-pyrimethamine) has been implemented for uncomplicated falciparum malaria since 2010. But for vivax malaria drug policy remained unchanged i.e., chloroqine and primaquine. We observed the impact of this intervention in urban Kolkata by analyzing data from the Malaria Clinic from 2001 to 2013. In Kolkata, we observed that Plasmodium vivax was perennial, whereas P. falciparum infection was seasonal. Before ACT implementation, the proportion of P. falciparum was as high as 50% and it steadily decreased during 4 successive years post intervention. No change was observed in the number of P. vivax cases. ACT may be an effective measure in reducing falciparum malaria cases. Artemisinin-derivative combination therapies should be explored in vivax malaria to reduce the overall burden of malaria.

引用

页码：321 / 323

页数：3

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