Reaching a moveable visual target: Dissociations in brain tumour patients

被引:14
作者
Buiatti, Tania [1 ,2 ]
Skrap, Miran [3 ]
Shallice, Tim [1 ,4 ]
机构
[1] SISSA, Cognit Neurosci Sect, I-34014 Trieste, Italy
[2] Univ Udine, Dept Human Sci, I-33100 Udine, Italy
[3] Azienda Osped Univ Santa Maria della Misericordia, Neurosurg Unit, Udine, Italy
[4] UCL, Inst Cognit Neurosci, London, England
关键词
Automatic pilot; Optic Ataxia; Posterior parietal cortex; Pointing to fixatable targets; Pointing to peripheral targets; On-line movement correction; POSTERIOR PARIETAL CORTEX; CASE SERIES INVESTIGATIONS; OPTIC ATAXIA; RESPONSE-INHIBITION; AUTOMATIC PILOT; ONLINE CONTROL; HAND; LESION; LOCALIZATION; MECHANISMS;
D O I
10.1016/j.bandc.2013.02.004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Damage to the posterior parietal cortex (PPC) can lead to Optic Ataxia (OA), in which patients misreach to peripheral targets. Recent research suggested that the PPC might be involved not only in simple reaching tasks toward peripheral targets, but also in changing the hand movement trajectory in real time if the target moves. The present study investigated whether patients with a lesion arising from operation for prefrontal, premotor or parietal tumours are selectively impaired in three experimental pointing conditions: (i) pointing to peripheral targets, (ii) pointing to fixatable targets, and (iii) pointing to moved targets (on-line movement corrections). The study confirmed the selective importance of the parietal cortex in all three tasks. Surprisingly, given clinical claims about OA, the degree of peripheral reaching errors correlated strongly in parietal patients with that to fixatable targets. However, there was no relation between peripheral reaching errors and the 'shift cost' of making on-line correction to moved targets, and classical double dissociations between the two skills were observed. The findings suggest that deficits in pointing to peripheral and to moved targets reflect two at least partly independent processes. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:6 / 17
页数:12
相关论文
共 47 条
[1]  
[Anonymous], 1988, NEUROPSYCHOLOGY MENT
[2]   Online Control of Hand Trajectory and Evolution of Motor Intention in the Parietofrontal System [J].
Archambault, Philippe S. ;
Ferrari-Toniolo, Simone ;
Battaglia-Mayer, Alexandra .
JOURNAL OF NEUROSCIENCE, 2011, 31 (02) :742-752
[3]   Cortical Mechanisms for Online Control of Hand Movement Trajectory: The Role of the Posterior Parietal Cortex [J].
Archambault, Philippe S. ;
Caminiti, Roberto ;
Battaglia-Mayer, Alexandra .
CEREBRAL CORTEX, 2009, 19 (12) :2848-2864
[4]   Cortical and subcortical contributions to stop signal response inhibition: Role of the subthalamic nucleus [J].
Aron, AR ;
Poldrack, RA .
JOURNAL OF NEUROSCIENCE, 2006, 26 (09) :2424-2433
[5]   Inhibition and the right inferior frontal cortex [J].
Aron, AR ;
Robbins, TW ;
Poldrack, RA .
TRENDS IN COGNITIVE SCIENCES, 2004, 8 (04) :170-177
[6]  
Balint R, 1909, MON PSYCHIATR NEUROL, V25, P51
[7]   Voxel-based lesion-symptom mapping [J].
Bates, E ;
Wilson, SM ;
Saygin, AP ;
Dick, F ;
Sereno, MI ;
Knight, RT ;
Dronkers, NF .
NATURE NEUROSCIENCE, 2003, 6 (05) :448-450
[8]   Optic ataxia as a result of the breakdown of the global tuning fields of parietal neurones [J].
Battaglia-Mayer, A ;
Caminiti, R .
BRAIN, 2002, 125 :225-237
[9]  
Battaglini P. P., 1998, PFLUGERS ARCH EUROPE, V437, pR28
[10]   Apraxias [J].
Binkofski F. ;
Fink G. .
Der Nervenarzt, 2005, 76 (4) :493-512