Emergence of OXA-48 and OXA-181 Carbapenemases among Enterobacteriaceae in South Africa and Evidence of In Vivo Selection of Colistin Resistance as a Consequence of Selective Decontamination of the Gastrointestinal Tract

被引：97

作者：

Brink, Adrian J. ^{[1
]}

Coetzee, Jennifer ^{[2
]}

Corcoran, Craig ^{[2
]}

Clay, Cornelis G. ^{[2
]}

Hari-Makkan, Danusha ^{[2
]}

Jacobson, Rachael K. ^{[3
]}

Richards, Guy A. ^{[4
]}

Feldman, Charles ^{[5
]}

Nutt, Louise ^{[6
]}

van Greune, Johan ^{[7
]}

Deetlefs, J. D. ^{[7
]}

Swart, Karin ^{[8
]}

Devenish, Lesley ^{[8
]}

Poirel, Laurent ^{[9
,10
]}

Nordmann, Patrice ^{[9
,10
]}

机构：

[1] Milpark Hosp, Ampath Natl Lab Serv, Dept Clin Microbiol, Johannesburg, South Africa

[2] Natl Reference Lab, Ampath Natl Lab Serv, Dept Clin Microbiol & Mol Biol, Centurion, South Africa

[3] Groote Schuur Hosp, Ctr Trop Opportunist & Hosp Infect, Natl Inst Communicable Dis, ZA-7925 Cape Town, South Africa

[4] Charlotte Maxeke Johannesburg Acad Hosp, Dept Crit Care, Johannesburg, South Africa

[5] Charlotte Maxeke Johannesburg Acad Hosp, Dept Med, Div Pulmonol, Johannesburg, South Africa

[6] Ampath Natl Lab Serv, Dept Clin Microbiol, Port Elizabeth, South Africa

[7] Ampath Natl Lab Serv, Dept Clin Microbiol, Cape Town, South Africa

[8] Netcare Grp, Clin Infect Prevent Specialists, Johannesburg, South Africa

[9] Hosp Bicetre, AP HP, Fac Med, Serv Bacteriol Virol,INSERM U914 Emerging Resista, K Bicetre, France

[10] Univ Paris 11, K Bicetre, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 01期

关键词：

CRITICALLY-ILL PATIENTS; METHANESULFONATE; INFECTIONS;

D O I：

10.1128/JCM.02234-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study reports on the emergence of OXA-48-like carbapenemases among isolates of Enterobacteriaceae in South Africa. In addition, the emergence during therapy of a colistin-resistant OXA-181-producing Klebsiella pneumoniae isolate was documented following selective digestive tract decontamination with oral colistin, which is therefore strongly discouraged.

引用

页码：369 / 372

页数：4

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