Protective effect of pioglitazone on morphine-induced neuroinflammation in the rat lumbar spinal cord

被引：18

作者：

Charkhpour, Mohammad ^{[1
]}

Ghavimi, Hamed ^{[2
]}

Ghanbarzadeh, Saeed ^{[3
]}

Yousefi, Bahman ^{[4
,5
]}

Khorrami, Arash ^{[1
]}

Mesgari, Mehran ^{[6
]}

Hassanzadeh, Kambiz ^{[7
,8
]}

机构：

[1] Tabriz Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Tabriz, Iran

[2] Zanjan Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Zanjan, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Dept Pharmaceut, Tabriz, Iran

[4] Tabriz Univ Med Sci, Fac Pharm, Dept Biochem & Clin Labs, Tabriz, Iran

[5] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[6] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[7] Kurdistan Univ Med Sci, Fac Med, Cellular & Mol Res Ctr, Sanandaj, Iran

[8] Kurdistan Univ Med Sci, Fac Med, Dept Physiol & Pharmacol, Sanandaj, Iran

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2015年 / 22卷

关键词：

Pioglitazone; Morphine; Neuroinflammation; GW-9662; PPAR-gamma; GAMMA AGONISTS; TOLERANT RATS; RECEPTOR; HYPERALGESIA; INFLAMMATION; ACTIVATION; ANALGESIA;

D O I：

10.1186/s12929-015-0187-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Background: Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated receptor gamma (PPAR-gamma) agonist, on the morphine-induced neuroinflammation in the lumbar region of the male Wistar rat spinal cord. Results: Co-administration of the pioglitazone with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin 6) and nuclear factor-kappa B activity. Administration of the GW-9662 antagonized the above mentioned effects of the pioglitazone. Conclusions: It is concluded that oral administration of the pioglitazone attenuates morphine-induced tolerance and the neuroinflammation in the lumbar region of the rat spinal cord. This action of the pioglitazone may be, at least in part, due to an interaction with the spinal pro-inflammatory cytokine expression and the nuclear factor-kappa B activity.

引用

页数：6

共 27 条

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