Dysfunction of the Innate Immune System During Sepsis: A Call for Research

被引:4
作者
Bickler, Stephen W. [1 ]
De Maio, Antonio [1 ,2 ]
机构
[1] Univ Calif San Diego, Dept Surg, San Diego, CA 92103 USA
[2] Univ Calif San Diego, Ctr Invest Hlth & Educ Dispar, San Diego, CA 92103 USA
关键词
bone marrow dysfunction; inflammation; inflammatory response; immunosuppression; lipopolysaccharide; multiple organ failure; sepsis; INJURY; PATHOPHYSIOLOGY; APOPTOSIS;
D O I
10.1097/CCM.0b013e318270e57b
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:364 / 365
页数:2
相关论文
共 16 条
[1]   Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care [J].
Angus, DC ;
Linde-Zwirble, WT ;
Lidicker, J ;
Clermont, G ;
Carcillo, J ;
Pinsky, MR .
CRITICAL CARE MEDICINE, 2001, 29 (07) :1303-1310
[2]   Period of Irreversible Therapeutic Intervention during Sepsis Correlates with Phase of Innate Immune Dysfunction [J].
Cauvi, David M. ;
Song, Donghuan ;
Vazquez, Daniel E. ;
Hawisher, Dennis ;
Bermudez, Jose A. ;
Williams, Michael R. ;
Bickler, Stephen ;
Coimbra, Raul ;
De Maio, Antonio .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (24) :19804-19815
[3]   Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment [J].
Docke, WD ;
Randow, F ;
Syrbe, U ;
Krausch, D ;
Asadullah, K ;
Reinke, P ;
VolK, HD ;
Kox, W .
NATURE MEDICINE, 1997, 3 (06) :678-681
[4]   DOWN-REGULATION OF PROINFLAMMATORY CYTOKINE RELEASE IN WHOLE-BLOOD FROM SEPTIC PATIENTS [J].
ERTEL, W ;
KREMER, JP ;
KENNEY, J ;
STECKHOLZER, U ;
JARRAR, D ;
TRENTZ, O ;
SCHILDBERG, FW .
BLOOD, 1995, 85 (05) :1341-1347
[5]   Innate Immune Function and Mortality in Critically Ill Children With Influenza: A Multicenter Study [J].
Hall, Mark W. ;
Geyer, Susan M. ;
Guo, Chao-Yu ;
Panoskaltsis-Mortari, Angela ;
Jouvet, Philippe ;
Ferdinands, Jill ;
Shay, David K. ;
Nateri, Jyotsna ;
Greathouse, Kristin ;
Sullivan, Ryan ;
Tram Tran ;
Keisling, Shannon ;
Randolph, Adrienne G. .
CRITICAL CARE MEDICINE, 2013, 41 (01) :224-236
[6]   Outcome after hemorrhagic shock in trauma patients [J].
Heckbert, SR ;
Vedder, NB ;
Hoffman, W ;
Winn, RK ;
Hudson, LD ;
Jurkovich, GJ ;
Copass, MK ;
Harlan, JM ;
Rice, CL ;
Maier, RV .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1998, 45 (03) :545-549
[7]   Selective defects of T lymphocyte function in patients with lethal intraabdominal infection [J].
Heidecke, CD ;
Hensler, T ;
Weighardt, H ;
Zantl, N ;
Wagner, H ;
Siewert, JR ;
Holzmann, B .
AMERICAN JOURNAL OF SURGERY, 1999, 178 (04) :288-292
[8]   Tilting toward immunosuppression [J].
Hotchkiss, Richard S. ;
Coopersmith, Craig M. ;
McDunn, Jonathan E. ;
Ferguson, Thomas A. .
NATURE MEDICINE, 2009, 15 (05) :496-497
[9]   Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans [J].
Hotchkiss, RS ;
Tinsley, KW ;
Swanson, PE ;
Schmieg, RE ;
Hui, JJ ;
Chang, KC ;
Osborne, DF ;
Freeman, BD ;
Cobb, JP ;
Buchman, TG ;
Karl, IE .
JOURNAL OF IMMUNOLOGY, 2001, 166 (11) :6952-6963
[10]   Medical progress: The pathophysiology and treatment of sepsis. [J].
Hotchkiss, RS ;
Karl, IE .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (02) :138-150