Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction

被引：93

作者：

Iwama, H ^{[1
]}

Uemura, S ^{[1
]}

Naya, N ^{[1
]}

Imagawa, K ^{[1
]}

Takemoto, Y ^{[1
]}

Asai, O ^{[1
]}

Onoue, K ^{[1
]}

Okayama, S ^{[1
]}

Somekawa, S ^{[1
]}

Kida, Y ^{[1
]}

Takeda, Y ^{[1
]}

Nakatani, K ^{[1
]}

Takaoka, M ^{[1
]}

Kawata, H ^{[1
]}

Horii, M ^{[1
]}

Nakajima, T ^{[1
]}

Dot, N ^{[1
]}

Salto, Y ^{[1
]}

机构：

[1] Nara Med Univ, Dept Med, Kashihara, Nara 634, Japan

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2006年 / 47卷 / 08期

关键词：

D O I：

10.1016/j.jacc.2005.11.064

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES Our aim was to investigate cardiac expression of placental growth factor (PIGF) and its clinical significance in patients with acute myocardial infarction (AMI). BACKGROUND Placental growth factor is known to stimulate wound healing by activating mononuclear cells and inducing angiogenesis. The clinical significance of PIGF in AMI is not yet known. METHODS Fifty-five AMI patients and 43 control subjects participated in the study. Peripheral blood sampling was performed on days 1, 3, and 7 after AMI. Blood was also sampled from the coronary artery (CAos) and the coronary sinus (CS), before and after acute coronary recanalization. Cardiac expression of PIGF was analyzed in a mouse AMI model. RESULTS In AMI patients, peripheral plasma PIGF levels on day 3 were significantly higher than in control subjects. Plasma PIGF levels just after recanalization were significantly higher in the CS than the CAos, which indicates cardiac production and release of PIGF. Peripheral plasma levels of PIGF on day 3 were negatively correlated with the acute phase left ventricular ejection fraction (LVEF), positively correlated with both acute phase peak peripheral monocyte counts and chronic phase changes in LVEF. Placental growth factor messenger ribonucleic acid expression was 26.6-fold greater in a mouse AMI model than in shamoperated mice, and PlGF was expressed mainly in endothelial cells within the infarct region. CONCLUSIONS Placental growth factor is rapidly produced in infarct myocardium, especially by endothelial cells during the acute phase of myocardial infarction. Placental growth factor might be over-expressed to compensate the acute ischemic damage, and appears to then act to improve LVEF during the chronic phase.

引用

页码：1559 / 1567

页数：9

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