Acute effects of three club drugs on the striatum of rats: Evaluation by quantitative autoradiography with [18F]FDOPA

被引：4
作者：
Fang, Chun-Kai [1 ,2 ]
Chen, Hong-Wen [3 ,4 ]
Wang, Wei-Hsun [1 ,5 ]
Liu, Ren-Shen [6 ,7 ]
Hwang, Jeng-Jong [1 ]
机构：
[1] Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan
[2] Mackay Mem Hosp, Dept Psychiat, Taipei, Taiwan
[3] Mackay Mem Hosp, Dept Radiat Oncol, Taipei, Taiwan
[4] Mackay Mem Hosp, Hosp Ctr, Taipei, Taiwan
[5] Changhua Christian Hosp, Dept Orthoped Surg, Changhua, Taiwan
[6] Vet Gen Hosp, Dept Nucl Med, Taipei, Taiwan
[7] Vet Gen Hosp, Natl PET Ctr, Taipei, Taiwan
来源：
APPLIED RADIATION AND ISOTOPES | 2013年 / 77卷
关键词：
Cocaine; Methamphetamine; Ketamine; Quantitative autoradiography; F-18]FDOPA; Striatum/frontal cortex binding ratio; POSITRON-EMISSION-TOMOGRAPHY; DOPAMINE RELEASE; KETAMINE ISOMERS; YOUNG-ADULTS; METHAMPHETAMINE; COCAINE; RECEPTORS; BRAIN; TRANSPORTER; SEROTONIN;
D O I：
10.1016/j.apradiso.2013.03.091
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this work, we used quantitative autoradiography to study the acute effect of cocaine, methamphetamine, and ketamine on the uptake of [(18)]FDOPA in the striatum of rats. Drugs were treated 0.5 h before (pre-treated), and 1.5 h after (post-treated) [(18)]FDOPA injections, rats were then sacrificed at 2 h post [F-18]FDOPA injections to determine the striatum/frontal cortex binding ratios in the striatum. The ratios were lower in the post-treated groups than those of the pre-treated groups, suggesting a net effect of inhibition of trapping of the tracer. The order of uptake inhibition is: ketamine > methamphetamine > cocaine. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：153 / 159
页数：7
相关论文
共 58 条
[1]   DETERMINATION OF PLASMA [F-18] 6-FLUORODOPA DURING POSITRON EMISSION TOMOGRAPHY - ELIMINATION AND METABOLISM IN CARBIDOPA TREATED SUBJECTS [J].
BOYES, BE ;
CUMMING, P ;
MARTIN, WRW ;
MCGEER, EG .
LIFE SCIENCES, 1986, 39 (23) :2243-2252
[2]   DIFFERING PATTERNS OF STRIATAL F-18 DOPA UPTAKE IN PARKINSONS-DISEASE, MULTIPLE SYSTEM ATROPHY, AND PROGRESSIVE SUPRANUCLEAR PALSY [J].
BROOKS, DJ ;
IBANEZ, V ;
SAWLE, GV ;
QUINN, N ;
LEES, AJ ;
MATHIAS, CJ ;
BANNISTER, R ;
MARSDEN, CD ;
FRACKOWIAK, RSJ .
ANNALS OF NEUROLOGY, 1990, 28 (04) :547-555
[3]   Effects of toxic doses of methamphetamine (METH) on dopamine D1 receptors in the mouse brain [J].
Cadet, JL ;
Ladenheim, B ;
Hirata, H .
BRAIN RESEARCH, 1998, 786 (1-2) :240-242
[4]   ROUTES OF ADMINISTRATION AND EFFECT OF CARBIDOPA PRETREATMENT ON 6-[F-18]FLUORO-L-DOPA/PET SCANS IN NONHUMAN-PRIMATES [J].
CHAN, GLY ;
DOUDET, DJ ;
DOBKO, T ;
HEWITT, KA ;
SCHOFIELD, P ;
PATE, BD ;
RUTH, TJ .
LIFE SCIENCES, 1995, 56 (21) :1759-1766
[5]   Robotic synthesis of 6-[18F]fluoro-L-dopa [J].
Chang, CW ;
Wang, HE ;
Lin, HM ;
Chtsai, CS ;
Chen, JB ;
Liu, RS .
NUCLEAR MEDICINE COMMUNICATIONS, 2000, 21 (09) :799-802
[6]   Use of ecstasy and other psychoactive substances among school-attending adolescents in Taiwan: national surveys 2004-2006 [J].
Chen, Wei J. ;
Fu, Tsung-Chieh ;
Ting, Te-Tien ;
Huang, Wei-Lun ;
Tang, Guang-Mang ;
Hsiao, Chuhsing Kate ;
Chen, Chuan-Yu .
BMC PUBLIC HEALTH, 2009, 9
[7]   In vivo regulation of DOPA decarboxylase by dopamine receptors in rat brain [J].
Cumming, P ;
Ase, A ;
Laliberte, C ;
Kuwabara, H ;
Gjedde, A .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (11) :1254-1260
[8]   The kinetic behaviour of [3H]DOPA in living rat brain investigated by compartmental modelling of static autoradiograms [J].
Deep, P ;
Kuwabara, H ;
Gjedde, A ;
Cumming, P .
JOURNAL OF NEUROSCIENCE METHODS, 1997, 78 (1-2) :157-168
[9]   PREPARATION OF [F-18]5-FLUORO-DOPA WITH REACTOR-PRODUCED FLUORINE-18 [J].
FIRNAU, G ;
NAHMIAS, C ;
GARNETT, S .
INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1973, 24 (03) :182-184
[10]   A rapid and reversible change in dopamine transporters induced by methamphetamine [J].
Fleckenstein, AE ;
Metzger, RR ;
Gibb, JW ;
Hanson, GR .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 323 (2-3) :R9-R10
123456