Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene

被引：16

作者：

Chen, Meiwan ^{[2
]}

Zhang, Jinming ^{[2
]}

Yu, Siqin ^{[3
]}

Wang, Shengpeng ^{[2
]}

Zhang, Zaijun ^{[2
,4
]}

Chen, Jianqiang ^{[1
]}

Xiao, Jian ^{[1
]}

Wang, Yitao ^{[2
]}

机构：

[1] Wenzhou Med Coll, Cixi Hosp, Sch Pharm, Wenzhou 325035, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China

[3] Beijing DDS Venturepharm T Corp, Beijing 100097, Peoples R China

[4] Jinan Univ, Coll Pharm, Inst New Drug Res, Guangdong Prov Key Lab Pharmacodynam Constituents, Jinan 510632, Guangdong, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷

关键词：

CISPLATIN-BASED CHEMOTHERAPY; CELL-CYCLE ARREST; IN-VITRO; APOPTOSIS; COMBINATION; INDUCTION; TAXANES;

D O I：

10.1155/2012/259523

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

In the past decade, beta-elemene played an important role in enhancing the effects of many anticancer drugs and was widely used in the treatment of different kinds of malignancies and in reducing the side effects of chemotherapy. Further study showed that it is also a promising anti-lung cancer drug. However, the clinical application of beta-elemene was limited by its hydrophobic property, poor stability, and low bioavailability. With the development of new excipients and novel technologies, plenty of novel formulations of beta-elemene have improved dramatically, which provide a positive perspective in terms of clinical application for beta-elemene. Liposome as a drug delivery system shows great advantages over traditional formulations for beta-elemene. In this paper, we summarize the advanced progress being made in anti-lung cancer activity and the new liposomes delivery systems of beta-elemene. This advancement is expected to improve the level of pharmacy research and provide a stronger scientific foundation for further study on beta-elemene.

引用

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