Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus

被引：60
作者：
Li, HB
Zhou, CX
Pan, YX
Gao, XZ
Wu, XM
Bai, H
Zhou, LF
Chen, Z
Zhang, SL
Shi, SY
Luo, JL
Xu, JH
Chen, LR
Zheng, XX
Zhao, Y [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China
[2] Zhejiang Hisun Nat Pharmaceut R&D Co Ltd, Hangzhou, Peoples R China
[3] Zhejiang Univ, Sch Med, Inst Infect Dis, Hosp 1, Hangzhou, Peoples R China
[4] Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Dept Biomed Engn, Hangzhou, Peoples R China
来源：
PLANTA MEDICA | 2005年 / 71卷 / 12期
关键词：
anti-virus; Ranunculus sieboldii; Ranunculus sceleratus; Ranunculaceae; hepatitis B virus; Herpes simplex virus type 1; flavone glycosides;
D O I：
10.1055/s-2005-873169
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4prime-O-alpha-rhamnopyranoside (1), apigenin 7-O-beta-glucopyranosyl-4prime-O-alpha-rhamnopyranoside (4), tricin 7-O-beta-glucopyranoside (5), tricin (12), and isoscopoletin (18) possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde (19) exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover anddevelop new antiviral agents.
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收藏
页码：1128 / 1133
页数：6
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