Synthesis of a new amphiphilic ortho-carborane as a potential BNCT agent:: 4-[N,N-formyl-(ortho-carboranylmethyl)-amino]benzoyl-L-glutamic acid.

被引：9
作者：
Rho, KY
Cho, YJ
Yoon, CM [1 ]
机构：
[1] Korea Univ, Coll Sci & Technol, Dept Chem, Chungnam 339700, South Korea
[2] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 26期
基金：
新加坡国家研究基金会;
关键词：
D O I：
10.1016/S0040-4039(99)00853-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A 1,2-dicarba-closo-dodecaboranyl derivative (8) and its disodium salt (9) were prepared from 4-aminobenzoic acid (1). The water solubility and the biological data (toxicity and cell-uptake) of the disodium salt (9) were identified to be enough for clinical trial. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4821 / 4824
页数：4
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