2-Amino-3-cyano-4-(5-arylisoxazol-3-yl)-4H-chromenes: Synthesis and In Vitro Cytotoxic Activity

被引：51

作者：

Akbarzadeh, Tahmineh ^{[1
,2
]}

Rafinejad, Ali ^{[1
,2
]}

Mollaghasem, Javad Malekian ^{[1
,2
]}

Safavi, Maliheh ^{[1
,2
,3
]}

Fallah-Tafti, Asal ^{[1
,2
]}

Pordeli, Mahboobeh ^{[3
]}

Ardestani, Sussan Kabudanian ^{[3
]}

Shafiee, Abbas ^{[1
,2
]}

Foroumadi, Alireza ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran, Iran

[2] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

[3] Univ Tehran, Inst Biochem & Biophys, Dept Biochem, Tehran, Iran

来源：

ARCHIV DER PHARMAZIE | 2012年 / 345卷 / 05期

关键词：

4-(5-Arylisoxazol-3-yl)-4H-chromenes; Cancer; Cytotoxic activity; Synthesis; THROUGHPUT SCREENING ASSAY; APOPTOSIS INDUCERS; SERIES; DISCOVERY; 4-ARYL-4H-CHROMENES; PROLIFERATION;

D O I：

10.1002/ardp.201100345

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 4-aryl-4H-chromenes bearing a 5-arylisoxazol-3-yl moiety at the C-4 position were prepared as potential anticancer agents. The in vitro cytotoxic activity of the synthesized compounds was investigated against a panel of tumor cell lines including MCF-7 (breast cancer), KB (nasopharyngeal epidermoid carcinoma), Hep-G2 (liver carcinoma), MDA-MB-231 (breast cancer), and SKNMC (human neuroblastoma) using the MTT colorimetric assay. Doxorubicin, a well-known anticancer drug, was used as positive standard drug. Among the synthesized compounds, the 5-(3-methylphenyl)isoxazol-3-yl analog (7j) showed the most potent cytotoxic activity against all five human tumor cell lines.

引用

页码：386 / 392

页数：7

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