A Review of Cyanoacetyl Indoles (CAIs): Versatile Starting Materials in Organic Synthesis

被引：10

作者：

Govender, Thavendran ^{[1
]}

Maguire, Glenn E. M. ^{[1
,2
]}

Kruger, Hendrik G. ^{[1
]}

Shiri, Morteza ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Hlth Sci, Catalysis & Peptide Res Unit, ZA-4001 Durban, South Africa

[2] Univ KwaZulu Natal, Sch Chem, ZA-4001 Durban, South Africa

来源：

CURRENT ORGANIC SYNTHESIS | 2013年 / 10卷 / 05期

关键词：

Cyanoacetyl indoles (CAIs); Friedel-Crafts; cyclisation; heterocycles; indoles; pyridines; quinolines; PALLADIUM-CATALYZED REACTIONS; POT MULTICOMPONENT REACTIONS; MICROWAVE IRRADIATION; PYRIDINE-DERIVATIVES; EFFICIENT SYNTHESIS; 2-(INDOL-3-YL)PYRIDINE DERIVATIVES; INDOL-3-YL PYRIDINE; FACILE; FUNCTIONALIZATION; PYRROLES;

D O I：

10.2174/1570179411310050005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyanoacetylindoles (CAIs) are easily obtained from the reaction of indoles and cyanoacetic acid, and are used as versatile starting materials in the synthesis of different heterocycles. This review focuses on the application of CAIs to generate a large diversity of indolyl heterocycles such as pyrazoles, triazoles, pyridines, dihydropyridines, pyrimidines, ozathiols, thiophenes, oxazoles, quinolines and many other complex heterocycles.

引用

页码：737 / 750

页数：14

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