Stereospecific synthesis of (+)-oxybiotin from D-xylose

被引:6
作者
Popsavin, V [1 ]
Benedekovic, G [1 ]
Popsavin, M [1 ]
Miljkovic, D [1 ]
机构
[1] Univ Novi Sad, Fac Sci, Inst Chem, YU-21000 Novi Sad, Yugoslavia
关键词
(+)-oxybiotin; protected 2,5-anhydro pentoses; 2,3,4-trisubstituted tetrahydrofuranes; D-xylose;
D O I
10.1016/S0008-6215(01)00331-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new 14-step synthesis of ( +)-oxybiotin. an oxygen analogue of ( +)-biotin, was achieved starting from D-xylose by use of selected 2.5-anhydro sugar derivatives as key intermediates. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:459 / 465
页数:7
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