Recent advances in malaria drug discovery

被引：167

作者：

Biamonte, Marco A. ^{[1
]}

Wanner, Jutta ^{[2
]}

Le Roch, Karine G. ^{[3
]}

机构：

[1] Drug Discovery Trop Dis, San Diego, CA 92121 USA

[2] Hoffmann La Roche Inc, pRED, Pharma Res & Early Dev, Small Mol Res,Discovery Chem, Nutley, NJ 07110 USA

[3] Univ Calif Riverside, Dept Cell Biol & Neurosci, Ctr Dis Vector Res, Inst Integrat Genome Biol, Riverside, CA 92521 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Malaria; Antimalarial; Plasmodium; Drugs; Review; FALCIPARUM DIHYDROOROTATE DEHYDROGENASE; NAPHTHOQUINE COMBINATION THERAPY; RESISTANT PLASMODIUM-YOELII; PYRIMETHAMINE-SULFADOXINE RESISTANCE; UNCOMPLICATED PEDIATRIC MALARIA; ANTIMALARIAL ACTIVITY; IN-VITRO; ARTEMISININ-NAPHTHOQUINE; LEAD OPTIMIZATION; DIHYDROFOLATE-REDUCTASE;

D O I：

10.1016/j.bmcl.2013.03.067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This digest covers some of the most relevant progress in malaria drug discovery published between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such drugs can target the blood stage of the disease to alleviate the symptoms, the liver stage to prevent relapses, and the transmission stage to protect other humans. The pipeline for the blood stage is becoming robust, but this should not be a source of complacency, as the current therapies set a high standard. Drug discovery efforts directed towards the liver and transmission stages are in their infancy but are receiving increasing attention as targeting these stages could be instrumental in eradicating malaria. (C) 2013 Elsevier Ltd. All rights reserved:

引用

页码：2829 / 2843

页数：15

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