Homalomena pineodora essential oil nanoparticle inhibits diabetic wound pathogens

被引：31

作者：

Rozman, Nur Amiera Syuhada ^{[1
]}

Tong, Woei Yenn ^{[1
]}

Leong, Chean Ring ^{[1
]}

Anuar, Mohd Razealy ^{[1
]}

Karim, Sabrina ^{[1
]}

Ong, Siew Kooi ^{[1
]}

Yusof, Fahmi Asyadi ^{[1
]}

Tan, Wen-Nee ^{[2
]}

Sulaiman, Baharuddin ^{[3
]}

Ooi, Mei Lee ^{[4
]}

Lee, Kok Chang ^{[4
]}

机构：

[1] Univ Kuala Lumpur, Malaysian Inst Chem & Engn Technol, Drug Discovery & Delivery Res Lab, Lot 1988 Kawasan Perindustrian Bandar Vendor, Alor Gajah 78000, Melaka, Malaysia

[2] Univ Sains Malaysia, Sch Distance Educ, Gelugor 11800, Pulau Pinang, Malaysia

[3] Univ Sains Malaysia, Sch Biol Sci, Gelugor 11800, Pulau Pinang, Malaysia

[4] Univ Tunku Abdul Rahman, Fac Sci, Jalan Univ,Bandar Barat Perak Campus, Kampar 31900, Perak, Malaysia

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

CHITOSAN NANOPARTICLES; IN-VITRO; DELIVERY;

D O I：

10.1038/s41598-020-60364-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Essential oil of Homalomena pineodora inhibits diabetic pathogens; however, the activity was not sustainable when applied as wound dressing. This study aims to synthesise the essential oil nanoparticle using chitosan. The nanoparticles were synthesised with ion gelation method, confirmed by spectroscopic analysis. The spherical nanoparticles display a size of 70 nm, with strong surface charge of +24.10 mV. The nanoparticles showed an initial burst release followed by a slow release pattern for 72 h, following the first order of kinetic. The release behaviour was ideal for wound dressing. The antimicrobial activity was broad spectrum. The formation of nanoparticle enhanced the antimicrobial efficacy of the essential oil. The nanoparticle also showed a concentration-dependent killing behaviour on time-kill assay. In the 3D collagen wound models, the nanoparticles reduced the microbial growth by 60-80%. In conclusion, H. pineodora nanoparticles showed pharmaceutical potential in inhibiting microbial growth on diabetic ulcers.

引用

页数：11

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