Does Obesity Affect Fracture Healing in Children?

被引:22
作者
Lee, Rushyuan J. [1 ]
Hsu, Nigel N. [1 ]
Lenz, Colleen M. [1 ]
Leet, Arabella I. [2 ]
机构
[1] Johns Hopkins Univ, Dept Orthopaed Surg, Baltimore, MD USA
[2] Shriners Hosp Children, Honolulu, HI 96826 USA
关键词
BONE-MINERAL DENSITY; BODY-MASS INDEX; LEPTIN-DEFICIENT; BIOMECHANICAL ANALYSIS; RISK-FACTOR; OB RNA; EXPRESSION; CHILDHOOD; DIFFERENTIATION; ADIPOCYTES;
D O I
10.1007/s11999-012-2626-7
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Obesity is a risk factor for various orthopaedic diseases, including fractures. Obesity's influence on circulating hormones and cytokines and bone mineralization ultimately influences the body's osteogenic response and bone mineralization, potentially increasing the risk of fracture and impacting fracture healing. Does obesity delay fracture recovery in overweight or obese children as measured by the time to release to normal activity? Is this average time for return to activity influenced by the mechanism of the injury? Does obesity's effect on mineralization and loading in overweight or obese children lead to a greater proportion of upper extremity fracture versus lower extremity fracture? We prospectively followed 273 patients with nonpathologic long bone fractures treated from January 2010 to October 2011. Patients were stratified into obese/overweight, normal weight, and underweight groups. All patients were followed until release to regular activities (mean, 41 days; range, 13-100 days). Release to regular activities occurred sooner in obese/overweight than in normal weight patients: 39 and 42 days, respectively. A greater proportion of obese/overweight patients had low to moderate energy mechanisms of injury than did normal weight patients, but we found no difference between the groups in terms of return to activity when stratified by mechanism. There was also no difference in the proportion of upper extremity injuries between the two groups. Obese/overweight children did not have a delay in release to activities compared with children of normal weight. Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.
引用
收藏
页码:1208 / 1213
页数:6
相关论文
共 40 条
[1]  
[Anonymous], OB RAT ALL CHILDR US
[2]  
[Anonymous], OB LOW INC PRESCH CH
[3]  
[Anonymous], BAS CHILDH OB
[4]   Hypothalamic control of bone formation: Distinct actions of leptin and Y2 receptor pathways [J].
Baldock, PA ;
Sainsbury, A ;
Allison, S ;
Lin, EJD ;
Couzens, M ;
Boey, D ;
Enriquez, R ;
During, M ;
Herzog, H ;
Gardiner, EM .
JOURNAL OF BONE AND MINERAL RESEARCH, 2005, 20 (10) :1851-1857
[5]   Central (ICV) Leptin Injection Increases Bone Formation, Bone Mineral Density, Muscle Mass, Serum IGF-1, and the Expression of Osteogenic Genes in Leptin-Deficient ob/ob Mice [J].
Bartell, Shoshana M. ;
Rayalam, Srujana ;
Ambati, Suresh ;
Gaddam, Dhanunjaya R. ;
Hartzell, Diane L. ;
Hamrick, Mark ;
She, Jin-Xiong ;
Della-Fera, Mary Anne ;
Baile, Clifton A. .
JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (08) :1710-1720
[6]   A role for leptin and its cognate receptor in hematopoiesis [J].
Bennett, BD ;
Solar, GP ;
Yuan, JQ ;
Mathias, J ;
Thomas, GR ;
Matthews, W .
CURRENT BIOLOGY, 1996, 6 (09) :1170-1180
[7]   Effects of obesity on bone metabolism [J].
Cao, Jay J. .
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, 2011, 6
[8]   Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo [J].
Cornish, J ;
Callon, KE ;
Bava, U ;
Lin, C ;
Naot, D ;
Hill, BL ;
Grey, AB ;
Broom, N ;
Myers, DE ;
Nicholson, GC ;
Reid, IR .
JOURNAL OF ENDOCRINOLOGY, 2002, 175 (02) :405-415
[9]   A dynamic biomechanical analysis of the etiology of adolescent tibia vara [J].
Davids, JR ;
Huskamp, M ;
Bagley, AM .
JOURNAL OF PEDIATRIC ORTHOPAEDICS, 1996, 16 (04) :461-468
[10]   Biomechanical analysis of arm fracture in obese boys [J].
Davidson, PL ;
Goulding, A ;
Chalmers, DJ .
JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2003, 39 (09) :657-664