Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity

被引：132

作者：

Corlew, Rebekah ^{[1
,2
]}

Brasier, Daniel J. ^{[3
]}

Feldman, Daniel E. ^{[4
,5
]}

Philpot, Benjamin D. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Curriculum Neurobiol, Ctr Neurosci, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA

[3] Salk Inst Biol Studies, Syst Neurobiol Lab, La Jolla, CA 92037 USA

[4] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[5] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

来源：

NEUROSCIENTIST | 2008年 / 14卷 / 06期

关键词：

Presynaptic NMDA receptors; Timing-dependent long-term depression; Spike timing-dependent plasticity; Cortex; Development;

D O I：

10.1177/1073858408322675

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Many aspects of synaptic development, plasticity, and neurotransmission are critically influenced by NMDA-type glutamate receptors (NMDARs). Moreover, dysfunction of NMDARs has been implicated in a broad array of neurological disorders, including schizophrenia, stroke, epilepsy, and neuropathic pain. Classically, NMDARs were thought to be exclusively postsynaptic. However, substantial evidence in the past 10 years demonstrates that NMDARs also exist presynaptically and that presynaptic NMDA receptors (preNMDARs) modulate synapse function and have critical roles in plasticity at many synapses. Here the authors review current knowledge of the role of preNMDARs in synaptic transmission and plasticity, focusing on the neocortex. They discuss the prevalence, function, and development of these receptors, and their potential modification by experience and in brain pathology. NEUROSCIENTIST 14(6): 609-625, 2008. DOI: 10.1177/1073858408322675

引用

页码：609 / 625

页数：17

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