Regulations of sugar transporters: insights from yeast

被引：80

作者：

Horak, J. ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Physiol, Dept Membrane Transport, Vvi, CR-14220 Prague 4, Czech Republic

来源：

CURRENT GENETICS | 2013年 / 59卷 / 1-2期

关键词：

Glucose signalling; Sugar transporter; Sensing element; Yeast; SNF1; PROTEIN-KINASE; GLUCOSE-INDUCED INACTIVATION; MAL GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE REVEALS; INDIVIDUAL HEXOSE TRANSPORTERS; TERMINAL CYTOPLASMIC DOMAIN; SIGNAL-TRANSDUCTION PATHWAY; LACTOSE-GALACTOSE REGULON; DNA-BINDING PROTEIN; KLUYVEROMYCES-LACTIS;

D O I：

10.1007/s00294-013-0388-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transport across the plasma membrane is the first step at which nutrient supply is tightly regulated in response to intracellular needs and often also rapidly changing external environment. In this review, I describe primarily our current understanding of multiple interconnected glucose-sensing systems and signal-transduction pathways that ensure fast and optimum expression of genes encoding hexose transporters in three yeast species, Saccharomyces cerevisiae, Kluyveromyces lactis and Candida albicans. In addition, an overview of GAL- and MAL-specific regulatory networks, controlling galactose and maltose utilization, is provided. Finally, pathways generating signals inducing posttranslational degradation of sugar transporters will be highlighted.

引用

页码：1 / 31

页数：31

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