Review and update: Current treatment trends for patients with retinitis pigmentosa

被引：146

作者：

Shintani, Kelly ^{[2
]}

Shechtman, Diana L. ^{[1
]}

Gurwood, Andrew S. ^{[3
]}

机构：

[1] Nova SE Univ, Hlth Profess Div, Coll Optometry, Ft Lauderdale, FL 33328 USA

[2] Orinda Optometry Grp, Orinda, CA USA

[3] Penn Coll Optometry, Philadelphia, PA 19141 USA

来源：

OPTOMETRY-JOURNAL OF THE AMERICAN OPTOMETRIC ASSOCIATION | 2009年 / 80卷 / 07期

关键词：

Retinitis pigmentosa; Neuro-prosthetic devices; Gene therapy; Photoreceptor degeneration; Retinal transplantation; LEBERS CONGENITAL AMAUROSIS; HEREDITARY RETINAL DEGENERATIONS; OPTICAL COHERENCE TOMOGRAPHY; CILIARY NEUROTROPHIC FACTOR; VITAMIN-E SUPPLEMENTATION; CYSTOID MACULAR EDEMA; LOW-VISION CORRECTION; VISUAL-FIELD; STEM-CELLS; GENE-TRANSFER;

D O I：

10.1016/j.optm.2008.01.026

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

BACKGROUND: Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal disorders characterized by progressive photoreceptor apoptosis. It is the leading cause of inherited retinal degeneration associated blindness. RP has a unique set of clinical characteristics that make it a complex disease associated with distinct inheritance patterns. An understanding of the pathogenesis is essential in the process of the differential diagnosis and the development of treatment options. Recent developments in research are likely to expand the various therapeutic modalities to include gene therapy, pharmacologic treatment, cell transplantation, and neuro-prosthetic devices. METHODS: A literature search was performed to comprehensively review RP diagnosis, pathophysiology, and treatment. CONCLUSION: Advances in the understanding of the pathophysiology of RP are creating new opportunities for the treatment of this often visually debilitating eye condition. Optometrists, as primary eye care practitioners, should be aware of the inheritance, pathophysiology, and current treatment options for RP as well as treatments in development so that they can best care for their patients with inherited retinal disorders. Optometry 2009;80:384-401

引用

页码：384 / 401

页数：18

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