Effects of Antidepressant Treatment on Sexual Arousal in Depressed Women: A Preliminary fMRI Study

被引:8
作者
Yang, Jong-Chul [2 ,3 ,4 ,5 ]
Park, Jong-Il [4 ,5 ]
Kim, Gwang-Won [1 ]
Eun, Sung-Jong [6 ]
Lee, Moo-Suk [7 ]
Han, Kyung-Lae [8 ]
Chae, Jeong-Ho [9 ]
Jeong, Gwang-Woo [1 ]
机构
[1] Chonnam Natl Univ, Sch Med, Dept Radiol, Kwangju 501757, South Korea
[2] Chonbuk Natl Univ, Sch Med, Dept Psychiat, Jeonju, South Korea
[3] Inst Med Sci, Jeonju, South Korea
[4] Chonbuk Natl Univ Hosp, Dept Psychiat, Jeonju, South Korea
[5] Res Inst Clin Med, Jeonju, South Korea
[6] Hanlyo Univ, Dept Radiol, Gwangyang, South Korea
[7] Chonnam Natl Univ, Sch Med, Dept Psychiat, Kwangju 501757, South Korea
[8] Yesan Hosp, Dept Psychiat, Yesan, South Korea
[9] Catholic Univ Korea, Dept Psychiat, Coll Med, Seoul, South Korea
关键词
Sexual arousal; Depression; Women; Treatment; Functional magnetic resonance imaging (fMRI); Cerebral region; NOCTURNAL PENILE TUMESCENCE; BRAIN ACTIVATION; MIRTAZAPINE; DYSFUNCTION; SYMPTOMS; STIMULI; AREAS;
D O I
10.4306/pi.2012.9.4.379
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective There was a recent study to explore the cerebral regions associated with sexual arousal in depressed women using functional magnetic resonance imaging (fMRI). The purpose of this neuroimaging study was to investigate the effects of antidepressant treatment on sexual arousal in depressed women. Methods Seven depressed women with sexual arousal dysfunction (mean age: 41.7 +/- 13.8, mean scores of the Beck Depression Inventory (BDI) and the 17-item Hamilton Rating Scale for Depression (HAMD-17): 35.6 +/- 7.1 and 34.9 +/- 3.1, respectively) and nine healthy women (mean age: 40.3 +/- 11.6) underwent fMRI before and after antidepressant treatment. The fMRI paradigm contrasted a 1 minute rest period viewing non-erotic film with 4 minutes of sexual stimulation viewing an erotic video film. Data were analyzed by SPM 2. The relative number of pixels activated in each period was used as an index of activation. All depressed women were treated with mirtazapine (mean dosage: 37.5 mg/day) for 8 to 10 weeks. Results Levels of brain activity during sexual arousal in depressed women significantly increased with antidepressant treatment (p<0.05) in the regions of the hypothalamus (3.0% to 11.2%), septal area (8.6% to 27.8%) and parahippocampal gyrus (5.8% to 14.6%). Self-reported sexual arousal during visual sexual stimulation also significantly increased post-treatment, and severity of depressive symptoms improved, as measured by the BDI and HAMD-17 (p<0.05). Conclusion These results show that sexual arousal dysfunction of depressed women may improve after treatment of depression, and that this improvement is associated with increased activation of the hypothalamus, septal area, and parahippocampal gyrus during sexual arousal. Psychiatry Investig 2012;9:379-383
引用
收藏
页码:379 / 383
页数:5
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