A Radical View of Pathological Vasculature

被引：3

作者：

Alitalo, Kari ^{[1
]}

机构：

[1] Univ Helsinki, Biomedicum Helsinki, Mol Canc Biol Lab, Helsinki 00014, Finland

来源：

CELL METABOLISM | 2012年 / 16卷 / 03期

关键词：

DNA-DAMAGE RESPONSE;

D O I：

10.1016/j.cmet.2012.08.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Striking results reported by Okuno et al. (2012) in the July issue of Nature Medicine show that the ataxia telangiectasia mutated (ATM) kinase counteracts excessive oxygen radical production in immature angiogenic blood vessels. Its deletion results in activation of the mitogen-activated protein kinase p38 alpha and arrest of pathological angiogenesis.

引用

页码：287 / 288

页数：2

共 7 条

[1] VEGF inhibition: insights from preclinical and clinical studies [J].

Crawford, Yongping ;

Ferrara, Napoleone .

CELL AND TISSUE RESEARCH, 2009, 335 (01) :261-269

[2] The ATM protein kinase and cellular redox signaling: beyond the DNA damage response [J].

Ditch, Scott ;

Paull, Tanya T. .

TRENDS IN BIOCHEMICAL SCIENCES, 2012, 37 (01) :15-22

[3] Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells [J].

Ito, K ;

Hirao, A ;

Arai, F ;

Takubo, K ;

Matsuoka, S ;

Miyamoto, K ;

Ohmura, M ;

Naka, K ;

Hosokawa, K ;

Ikeda, Y ;

Suda, T .

NATURE MEDICINE, 2006, 12 (04) :446-451

[4] M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis [J].

Kubota, Yoshiaki ;

Takubo, Keiyo ;

Shimizu, Takatsune ;

Ohno, Hiroaki ;

Kishi, Kazuo ;

Shibuya, Masabumi ;

Saya, Hideyuki ;

Suda, Toshio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (05) :1089-1102

[5]

Okuno Y., 2012, NAT MED

[6] ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome [J].

Schneider, Jochen G. ;

Finck, Brian N. ;

Ren, Jie ;

Standley, Kara N. ;

Takagi, Masatoshi ;

Maclean, Kirsteen H. ;

Bernal-Mizrachi, Carlos ;

Muslin, Anthony J. ;

Kastan, Michael B. ;

Semenkovich, Clay F. .

CELL METABOLISM, 2006, 4 (05) :377-389

[7] Ataxia Telangiectasia Mutated (ATM)-mediated DNA Damage Response in Oxidative Stress-induced Vascular Endothelial Cell Senescence [J].

Zhan, Hong ;

Suzuki, Toru ;

Aizawa, Kenichi ;

Miyagawa, Kiyoshi ;

Nagai, Ryozo .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (38) :29662-29670

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