Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K-M from the Marine Fungus Chondrostereum sp

被引：20

作者：

Huang, Lei ^{[1
]}

Lan, Wen-Jian ^{[2
,3
]}

Deng, Rong ^{[4
]}

Feng, Gong-Kan ^{[4
]}

Xu, Qing-Yan ^{[5
]}

Hu, Zhi-Yu ^{[5
]}

Zhu, Xiao-Feng ^{[4
]}

Li, Hou-Jin ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[3] Guangdong Technol Res Ctr Adv Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[5] Xiamen Univ, Sch Life Sci, Xiamen 361102, Peoples R China

来源：

MARINE DRUGS | 2016年 / 14卷 / 09期

关键词：

Chondrostereum sp; chondrosterin; hirsutane; sesquiterpenoid; cytotoxicity; HIRSUTANE; ANTIBIOTICS; ACID;

D O I：

10.3390/md14090157

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

By the method of H-1 NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoidschondrosterins K-M (1-3) and the known sesquiterpenoid anhydroarthrosporone (4)were isolated from the marine fungus Chondrostereum sp. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Chondrosterin K is a rare hirsutane sesquiterpenoid, in which a methyl group was migrated from C-2 to C-6 and has a double bond between C-2 and C-3. Compounds 1-3 showed significant cytotoxicities against various cancer cell lines in vitro.

引用

页数：9

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