A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP

被引：156
作者：
Lauri, SE
Bortolotto, ZA
Bleakman, D
Ornstein, PL
Lodge, D
Isaac, JTR
Collingridge, GL [1 ]
机构：
[1] Univ Bristol, Sch Med, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
[2] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA
来源：
NEURON | 2001年 / 32卷 / 04期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
D O I：
10.1016/S0896-6273(01)00511-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The mechanisms involved in mossy fiber LTP in the hippocampus are not well established. In the present study, we show that the kainate receptor antagonist LY382884 (10 muM) is selective for presynaptic kainate receptors in the CA3 region of the hippocampus. At a concentration at which it blocks mossy fiber LTP, LY382884 selectively blocks the synaptic activation of a presynaptic kainate receptor that facilitates AMPA receptor-mediated synaptic transmission. Following the induction of mossy fiber LTP, there is a complete loss of the presynaptic kainate receptor-mediated facilitation of synaptic transmission. These results identify a central role for the presynaptic kainate receptor in the induction of mossy fiber LTP. In addition, these results suggest that the pathway by which kainate receptors facilitate glutamate release is utilized for the expression of mossy fiber LTP.
引用
收藏
页码：697 / 709
页数：13
相关论文
共 42 条
  • [1] The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events
    Anderson, WW
    Collingridge, GL
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 2001, 108 (01) : 71 - 83
  • [2] [Anonymous], 1991, HDB SYNCHROTRON RAD
  • [3] INDUCTION OF LTP IN THE HIPPOCAMPUS NEEDS SYNAPTIC ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS
    BASHIR, ZI
    BORTOLOTTO, ZA
    DAVIES, CH
    BERRETTA, N
    IRVING, AJ
    SEAL, AJ
    HENLEY, JM
    JANE, DE
    WATKINS, JC
    COLLINGRIDGE, GL
    [J]. NATURE, 1993, 363 (6427) : 347 - 350
  • [4] Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists
    Bleisch, TJ
    Ornstein, PL
    Allen, NK
    Wright, RA
    Lodge, D
    Schoepp, DD
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (09) : 1161 - 1166
  • [5] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS
    BLISS, TVP
    COLLINGRIDGE, GL
    [J]. NATURE, 1993, 361 (6407) : 31 - 39
  • [6] Bortolotto ZA, 2000, NATURE, V406, P957, DOI 10.1038/35023077
  • [7] Kainate receptors are involved in synaptic plasticity
    Bortolotto, ZA
    Clarke, VRJ
    Delany, CM
    Parry, MC
    Smolders, I
    Vignes, M
    Ho, KH
    Miu, P
    Brinton, BT
    Fantaske, R
    Ogden, A
    Gates, M
    Ornstein, PL
    Lodge, D
    Bleakman, D
    Collingridge, GL
    [J]. NATURE, 1999, 402 (6759) : 297 - 301
  • [8] THE ROLE OF CA2+ CHANNELS IN HIPPOCAMPAL MOSSY FIBER SYNAPTIC TRANSMISSION AND LONG-TERM POTENTIATION
    CASTILLO, PE
    WEISSKOPF, MG
    NICOLL, RA
    [J]. NEURON, 1994, 12 (02) : 261 - 269
  • [9] Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons
    Castillo, PE
    Malenka, RC
    Nicoll, RA
    [J]. NATURE, 1997, 388 (6638) : 182 - 186
  • [10] Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus
    Contractor, A
    Swanson, GT
    Sailer, A
    O'Gorman, S
    Heinemann, SF
    [J]. JOURNAL OF NEUROSCIENCE, 2000, 20 (22) : 8269 - 8278
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