Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer's disease

被引：34

作者：

Dahmcke, Christina Mackeprang ^{[1
]}

Buechmann-Moller, Stine ^{[2
]}

Jensen, Niels A. ^{[3
]}

Mitchelmore, Cathy ^{[1
]}

机构：

[1] Roskilde Univ Ctr, Eucaryot Cell Biol Res Grp, Dept Sci, Roskilde, Denmark

[2] Univ Zurich, Inst Cell Biol, CH-8093 Zurich, Switzerland

[3] Univ So Denmark, Mol Neurobiol Lab, Ctr Med Biotechnol, Odense C, Denmark

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2008年 / 38卷 / 04期

关键词：

CDKN1A; nuclear matrix; Alzheimer's disease; DNA replication;

D O I：

10.1016/j.mcn.2008.05.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to understand the gene-mediated processes underlying Sporadic Alzheimer's disease (AD), we carried out a subtractive cloning screen for novel AD candidate genes. We identified the gene encoding the DNA replication factor CIZ1 (CDKN1A interacting zinc finger protein 1) as being more highly expressed in Alzheimer tissue than in healthy brains. We show here that an isoform of CIZ1 which lacks a glutamine-rich region, due to alternative splicing in exon 8, is upregulated in AD brains relative to the full-length CIZ1 protein. We demonstrate for the first time that a minimal 28 amino acid sequence within this region is required for CIZ1 to associate with the nuclear matrix and to form nuclear foci. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：589 / 594

页数：6

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