LINC00152/miR-139-5p regulates gastric cancer cell aerobic glycolysis by targeting PRKAA1

被引：47
作者：
Sun, Keke [1 ]
Hu, Pingping [1 ]
Xu, Feng [1 ]
机构：
[1] Ningbo Univ, Med Sch, Yinzhou Hosp, Dept Gastroenterol, Ningbo, Zhejiang, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 97卷
关键词：
PRKAA1; MiR-139-5p; Gastric cancer; Glycolysis; LINC00152; NONCODING RNA LINC00152; EPITHELIAL-MESENCHYMAL TRANSITION; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; CYCLE PROGRESSION; MIR-139-5P; PROLIFERATION; EXPRESSION; APOPTOSIS; MIGRATION;
D O I：
10.1016/j.biopha.2017.11.015
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Gastric cancer is one of the most common cancers in the world and glycolysis is a major feature of gastric cancer. MicroRNAs (miRNAs) involve in gastric cancer cell proliferation, glycolysis and other cellular processes. MiR-139-5p is reported as a tumor suppressor in cancers, however, the role of miR-139-5p including glycolytic metabolism is unclear in gastric cancer. So, the purpose of the present study is to elucidate the underlying mechanism in gastric cancer metabolism mediated by miR-139-5p. Our results revealed that miR-139-5p inhibited glycolysis by regulating AMP-activated, alpha 1 catalytic subunit (PRKAA1) expression in gastric cancer cells. We also found that miR-139-5p was down-regulated by long intergenic non-coding RNA 152 (LINC00152) in gastric cancer cells. Our results indicate that LINC00152/miR-139-5p facilitates gastric cancer cell glycolysis by regulating PRKAA1 expression.
引用
收藏
页码：1296 / 1302
页数：7
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