Toll-like receptor 4 plays significant roles during allergic rhinitis

被引：35

作者：

Radman, M. ^{[1
]}

Golshiri, A. ^{[1
]}

Shamsizadeh, A. ^{[2
]}

Zainodini, N. ^{[3
]}

Bagheri, V. ^{[3
]}

Arababadi, M. K. ^{[3
]}

Kennedy, D. ^{[4
]}

机构：

[1] Rafsanjan Univ Med Sci, Fac Med, Dept Otolaryngol, Rafsanjan, Iran

[2] Rafsanjan Univ Med Sci, Physiol Pharmacol Res Ctr, Rafsanjan, Iran

[3] Rafsanjan Univ Med Sci, Immunol Infect Dis Res Ctr, Rafsanjan, Iran

[4] Griffith Univ, Eskitis Inst Drug Discovery, Sch Biomol & Phys Sci, Nathan, Qld 4111, Australia

来源：

ALLERGOLOGIA ET IMMUNOPATHOLOGIA | 2015年 / 43卷 / 04期

关键词：

Allergic rhinitis; TLR4; Inflammation; MONOCLONAL-ANTIBODY; GENE-EXPRESSION; TLR4; AGONISTS; UP-REGULATION; ASTHMA; INFLAMMATION; TOLL-LIKE-RECEPTOR-4; POLYMORPHISMS; ASSOCIATION; PATHWAYS;

D O I：

10.1016/j.aller.2014.04.006

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allergic rhinitis is a nasal hypersensitivity and allergic disease which leads to inflammation of nasal mucosa. Previous investigations revealed that innate immune receptors play a key role in the pathogenesis of inflammatory diseases including allergic diseases. Toll-like receptors (TLRs), which are important innate immune receptors, play crucial roles in the recognition of foreign antigens, including allergens, and subsequently for the induction of immune responses such as inflammation. There are several controversial reports regarding the roles of TLR4 in the pathogenesis of allergic rhinitis. This review presents current information regarding the roles of TLR4 in the pathogenesis of allergic rhinitis and the plausible mechanisms which lead to the expression and function of TLR4 in this disease. (C) 2014 SEICAP Published by Elsevier Espana, S.L.U. All rights reserved.

引用

页码：416 / 420

页数：5

共 44 条

[1] Lack of Association Between Chemokine Receptor 5 (CCR5) δ32 Mutation and Pathogenesis of Asthma in Iranian Patients [J].