Baseline brain activity changes in patients with clinically isolated syndrome revealed by resting-state functional MRI

被引:18
作者
Liu, Yaou [1 ]
Duan, Yunyun [1 ]
Liang, Peipeng [1 ]
Jia, Xiuqin [1 ]
Yu, Chunshui [1 ]
Ye, Jing [2 ]
Butzkueven, Helmut [3 ]
Dong, Huiqing [2 ]
Li, Kuncheng [1 ,4 ]
机构
[1] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
[2] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
[3] Univ Melbourne, Dept Med, Melbourne, Vic, Australia
[4] Beijing Key Lab MRI & Brain Informat, Beijing, Peoples R China
关键词
Clinically isolated syndrome; multiple sclerosis; resting-state fMRI; ALFF; DEFAULT-MODE NETWORK; MULTIPLE-SCLEROSIS; CAUDATE-NUCLEUS; OPTIC NEURITIS; CORTEX; FMRI; CONNECTIVITY; ANATOMY; MATTER; SIGNAL;
D O I
10.1258/ar.2012.120269
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: A clinically isolated syndrome (CIS) is the first manifestation of multiple sclerosis (MS). Previous task-related functional MRI studies demonstrate functional reorganization in patients with CIS. Purpose: To assess baseline brain activity changes in patients with CIS by using the technique of regional amplitude of low frequency fluctuation (ALFF) as an index in resting-state fMRI. Material and Methods: Resting-state fMRIs data acquired from 37 patients with CIS and 37 age- and sex-matched normal controls were compared to investigate ALFF differences. The relationships between ALFF in regions with significant group differences and the EDSS (Expanded Disability Status Scale), disease duration, and T2 lesion volume (T2LV) were further explored. Results: Patients with CIS had significantly decreased ALFF in the right anterior cingulate cortex, right caudate, right lingual gyrus, and right cuneus (P < 0.05 corrected for multiple comparisons using Monte Carlo simulation) compared to normal controls, while no significantly increased ALFF were observed in CIS. No significant correlation was found between the EDSS, disease duration, T2LV, and ALFF in regions with significant group differences. Conclusion: In patients with CIS, resting-state fMRI demonstrates decreased activity in several brain regions. These results are in contrast to patients with established MS, in whom ALFF demonstrates several regions of increased activity. It is possible that this shift from decreased activity in CIS to increased activity in MS could reflect the dynamics of cortical reorganization.
引用
收藏
页码:1073 / 1078
页数:6
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